ArticleCellular and molecular life sciences : CMLS2011
Identification of Treg-like cells in Tetraodon: insight into the origin of regulatory T subsets during early vertebrate evolution.
Article in Cellular and molecular life sciences : CMLS, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed, 97 citations in OpenAlex.
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- Cold-blooded vertebrates evolved regulatory B cells to participate in inflammatory diseases.Cell communication and signaling : CCS · 2025Article
- Primary regulatory T cell activator FOXP3 is present across Amphibia.Immunogenetics · 2025Article
- CD4 and LAG-3 from sharks to humans: related molecules with motifs for opposing functions.Frontiers in immunology · 2023Article
- Negative Regulatory Role of the Spring Viremia of Carp Virus Matrix Protein in the Host Interferon Response by Targeting the MAVS/TRAF3 Signaling Axis.Journal of virology · 2022Article
- Cluster of differentiation antigens: essential roles in the identification of teleost fish T lymphocytes.Marine life science & technology · 2022Review
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- Evolution of γ chain cytokines: Mechanisms, methods and applications.Computational and structural biotechnology journal · 2022Review
- RNA-Seq of Single Fish Cells - Seeking Out the Leukocytes Mediating Immunity in Teleost Fishes.Frontiers in immunology · 2022Review
- Identification and expression analysis of IL-2 receptors in large yellow croaker (Fish and shellfish immunology reports · 2021Article
- A method for making alignments of related protein sequences that share very little similarity; shark interleukin 2 as an example.Immunogenetics · 2021Review
- Differential immune responses of immunoglobulin Z subclass members in antibacterial immunity in a zebrafish model.Immunology · 2021Article
- A Single-Cell Transcriptome Profiling of Anterior Kidney Leukocytes From Nile Tilapia (Frontiers in immunology · 2021Article
- Ancient Cytokine Interleukin 15-Like (IL-15L) Induces a Type 2 Immune Response.Frontiers in immunology · 2020Article
- CD4: a vital player in the teleost fish immune system.Veterinary research · 2019Review
- Phylotranscriptomics suggests the jawed vertebrate ancestor could generate diverse helper and regulatory T cell subsets.BMC evolutionary biology · 2018Article
- Hints on T cell responses in a fish-parasite model: Enteromyxum leei induces differential expression of T cell signature molecules depending on the organ and the infection status.Parasites & vectors · 2018Article
- Interleukin (IL)-2 Is a Key Regulator of T Helper 1 and T Helper 2 Cytokine Expression in Fish: Functional Characterization of Two DivergentFrontiers in immunology · 2018Article
- Identification and characterization of T reg-like cells in zebrafish.The Journal of experimental medicine · 2017Article
- Changing expression of vertebrate immunity genes in an anthropogenic environment: a controlled experiment.BMC evolutionary biology · 2016Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
CD4(+)CD25(+)Foxp3(+) regulatory T cells (Treg cells) are critical for the maintenance of peripheral tolerance, and the suppression of autoimmune diseases and even tumors. Although Treg cells are well characterized in humans, little is known regarding their existence or occurrence in ancient vertebrates. In the present study, we report on the molecular and functional characterization of a Treg-like subset with the phenotype CD4-2(+)CD25-like(+)Foxp3-like(+) from a pufferfish (Tetraodon nigroviridis) model. Functional studies showed that depletion of this subset produced an enhanced mixed lymphocyte reaction (MLR) and nonspecific cytotoxic cell (NCC) activity in vitro, as well as inflammation of the intestine in vivo. The data presented here will not only enrich the knowledge of fish immunology but will also be beneficial for a better cross-species understanding of the evolutionary history of the Treg family and Treg-mediated regulatory networks in cellular immunity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.