ArticleLipids2010
Lipid analysis reveals quiescent and regenerating liver-specific populations of lipid droplets.
Article in Lipids, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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Who cites it
15 citing papers in PubMed.
- Lipid metabolism orchestrates liver regeneration: an integrated metabolic network.Journal of translational medicine · 2025Review
- Interplay between lipid droplets and alpha-synuclein: implication in Parkinson's disease pathogenesis.Frontiers in molecular neuroscience · 2025Review
- Cell lipid biology in infections: an overview.Frontiers in cellular and infection microbiology · 2023Review
- Mesenchymal stem cells ameliorate lipid metabolism through reducing mitochondrial damage of hepatocytes in the treatment of post-hepatectomy liver failure.Cell death & disease · 2021Article
- Cell cycle regulation in NAFLD: when imbalanced metabolism limits cell division.Hepatology international · 2020Review
- Mice depleted for Exchange Proteins Directly Activated by cAMP (Epac) exhibit irregular liver regeneration in response to partial hepatectomy.Scientific reports · 2019Article
- Atorvastatin provides a new lipidome improving early regeneration after partial hepatectomy in osteopontin deficient mice.Scientific reports · 2018Article
- Structure, Function and Metabolism of Hepatic and Adipose Tissue Lipid Droplets: Implications in Alcoholic Liver Disease.Current molecular pharmacology · 2017Review
- Fatty acids and cholesterol in the liver cell nuclei of hibernating Yakutian ground squirrels.Doklady. Biochemistry and biophysics · 2016Article
- Impaired cell proliferation in regenerating liver of 3 β-hydroxysterol Δ14-reductase (TM7SF2) knock-out mice.Cell cycle (Georgetown, Tex.) · 2016Article
- Cyclin D1 represses peroxisome proliferator-activated receptor alpha and inhibits fatty acid oxidation.Oncotarget · 2016Article
- Akt-mediated foxo1 inhibition is required for liver regeneration.Hepatology (Baltimore, Md.) · 2016Article
- The Dual Role of Nrf2 in Nonalcoholic Fatty Liver Disease: Regulation of Antioxidant Defenses and Hepatic Lipid Metabolism.BioMed research international · 2015Review
- Impaired liver regeneration in Ldlr-/- mice is associated with an altered hepatic profile of cytokines, growth factors, and lipids.Journal of hepatology · 2013Article
- Nonstructural 5A protein of hepatitis C virus interacts with pyruvate carboxylase and modulates viral propagation.PloS one · 2013Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mammalian liver, a key organ in lipid homeostasis, can accumulate increased amounts of lipids in certain physiological conditions including liver regeneration. Lipid droplets (LD), the lipid storage organelles in the cytoplasm, are composed of a core of neutral lipids (mainly triacylglycerols and cholesteryl esters) surrounded by a monolayer of phospholipids and cholesterol with associated proteins. It is recognized that LD lipid composition is cell- and environment-specific and enables LD to carry out specific functions, but few descriptive studies aiming to interpret such differences have been published. We characterized eight density fractions of LD isolated from quiescent (control) and regenerating liver after partial hepatectomy, and grouped populations according to their lipid composition. LD from quiescent liver resembled the cholesteryl ester storage LD found in steroidogenic tissues, whereas in the regenerating tissue they were similar to adipocyte LD. Specifically, there were large, light LD with increased triacylglycerol content, the hallmark of liver regeneration. The apparent volume of the dense LD was, however, lower than in the quiescent density-matched populations, concomitant with increased phosphatidylcholine and phosphatidylethanolamine and decreased neutral lipid content. Analysis of the lipid profile of LD populations from quiescent and regenerating tissue leads us to define four physiological LD phenotypes for rat liver.
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21063798What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.