ArticleJournal of computational neuroscience2011
A new 3D mass diffusion-reaction model in the neuromuscular junction.
Article in Journal of computational neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed, 11 citations in OpenAlex.
- A solvable model for the diffusion and reaction of neurotransmitters in a synaptic junction.BMC biophysics · 2011Article
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4 authors at 1 institution in 1 country.
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Abstract
A three-dimensional model of the reaction-diffusion processes of a neurotransmitter and its ligand receptor in a disk shaped volume is proposed which represents the transmission process of acetylcholine in the synaptic cleft in the neuromuscular junction. The behavior of the reaction-diffusion system is described by a three-dimensional diffusion equation with nonlinear reaction terms due to the rate processes of acetylcholine with the receptor. A new stable and accurate numerical method is used to solve the equations with Neumann boundaries in cylindrical coordinates. The simulation analysis agrees with experimental measurements of end-plate current, and agrees well with the results of the conformational state of the acetylcholine receptor as a function of time and acetylcholine concentration of earlier investigations with a smaller error compared to experiments. Asymmetric emission of acetylcholine in the synaptic cleft and the subsequent effects on open receptor population is simulated. Sensitivity of the open receptor dynamics to the changes in the diffusion parameters and neuromuscular junction volume is investigated. The effects of anisotropic diffusion and non-symmetric emission of transmitter at the presynaptic membrane is simulated.
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