ReviewEuropean journal of pediatrics2011
Clinical practice: proteinuria.
Review in European journal of pediatrics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 28 citations in OpenAlex.
- Acute kidney injury in children with haematological malignancy: a territory-wide study.Pediatric nephrology (Berlin, Germany) · 2023Article
- Evaluation of urinary haptoglobin level as a biomarker of diabetic nephropathy in children with type 1 diabetes.Pediatric nephrology (Berlin, Germany) · 2023Article
- How to define and assess the clinically significant causes of hematuria in childhood.Pediatric nephrology (Berlin, Germany) · 2023Article
- Retrospective evaluation of children with unilateral renal agenesis.Pediatric nephrology (Berlin, Germany) · 2021Article
- Enhanced MCP-1 Release in Early Autosomal Dominant Polycystic Kidney Disease.Kidney international reports · 2021Article
- Persistent Abnormalities of Fatty Acids Profile in Children With Idiopathic Nephrotic Syndrome in Stable Remission.Frontiers in pediatrics · 2020Article
- Simplified Algorithm for Evaluation of Proteinuria in Clinical Practice: How should A Clinician Approach?International journal of preventive medicine · 2019Article
- Urinary stone risk factors in the descendants of patients with kidney stone disease.Pediatric nephrology (Berlin, Germany) · 2018Article
- Observational
- Relation of resistın wıth obesity and some cardiovascular risk factors in hypertensive women.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2012Article
- Highlights for the management of a child with proteinuria and hematuria.International journal of pediatrics · 2012Article
- Acute hemorrhagic edema of young children: a concise narrative review.European journal of pediatrics · 2011Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Proteinuria detection in children is a challenge. Five percent to 15% and 0.4-1% of school children present either transient (benign) or persistent increased amount of protein in urine, respectively. Persistent proteinuria constitutes not only a sign of overt kidney disease but may also be the first indicator of silent renal damage. Proteinuria is a marker for hyperfiltration in individuals with reduced nephron mass and one of the most important independent risk factor for renal disease progression as well. It constitutes the single most important risk factor for future loss of kidney function, preceding glomerular filtration rate reduction. Further, proteinuria itself is diagnostic of cardiovascular disease with prognostic value and target organ involvement in high-risk populations such as diabetic, obese, hypertensive children, or those with known reduced renal mass or previous renal injury. Current strategies to prevent CKD progression, a concept known as renoprotection, are focused on reducing urinary protein excretion among other factors. Reversibility of organ damage in early stages is possible; therefore, pediatricians should screen children for proteinuria or microalbuminuria, mainly in high-risk groups.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.