ArticleEuropean archives of psychiatry and clinical neuroscience2011
A systematic experimental neuropsychological investigation of the functional integrity of working memory circuits in major depression.
Article in European archives of psychiatry and clinical neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.
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Who cites it
10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- Neurocognitive deficits in depression: a systematic review of cognitive impairment in the acute and remitted state.European archives of psychiatry and clinical neuroscience · 2023Pooled it
- Major depressive disorder is associated with broad impairments on neuropsychological measures of executive function: a meta-analysis and review.Psychological bulletin · 2013Pooled it
- The effect of bipolar bihemispheric tDCS on executive function and working memory abilities.Frontiers in psychology · 2023Article
- Distinct Neural Profiles of Frontoparietal Networks in Boys with ADHD and Boys with Persistent Depressive Disorder.Cognitive, affective & behavioral neuroscience · 2022Article
- Alterations in visual cortical activation and connectivity with prefrontal cortex during working memory updating in major depressive disorder.NeuroImage. Clinical · 2017Article
- Cognitive Dysfunction in Major Depressive Disorder. A Translational Review in Animal Models of the Disease.Pharmaceuticals (Basel, Switzerland) · 2016Review
- Clinical significance of knowledge about the structure, function, and impairments of working memory.Medical science monitor : international medical journal of experimental and clinical research · 2013Review
- Genetic polymorphisms of 5-HTT and DAT but not COMT differentially affect verbal and visuospatial working memory functioning.European archives of psychiatry and clinical neuroscience · 2012Article
- Response time variability and response inhibition predict affective problems in adolescent girls, not in boys: the TRAILS study.European child & adolescent psychiatry · 2012Article
- The role of the cerebellum in schizophrenia: from cognition to molecular pathways.Clinics (Sao Paulo, Brazil) · 2011Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Verbal and visuospatial working memory (WM) impairment is a well-documented finding in psychiatric patients suffering from major psychoses such as schizophrenia or bipolar affective disorder. However, in major depression (MDD) the literature on the presence and the extent of WM deficits is inconsistent. The use of a multitude of different WM tasks most of which lack process-specificity may have contributed to these inconsistencies. Eighteen MDD patients and 18 healthy controls matched with regard to age, gender and education were tested using process- and circuit-specific WM tasks for which clear brain-behaviour relationships had been established in prior functional neuroimaging studies. Patients suffering from acute MDD showed a selective impairment in articulatory rehearsal of verbal information in working memory. By contrast, visuospatial WM was unimpaired in this sample. There were no significant correlations between symptom severity and WM performance. These data indicate a dysfunction of a specific verbal WM system in acutely ill patients with MDD. As the observed functional deficit did not correlate with different symptom scores, further, longitudinal studies are required to clarify whether and how this deficit is related to illness acuity and clinical state of MDD patients.
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