ArticleEuropean journal of nuclear medicine and molecular imaging2011
Targeted multi-pinhole SPECT.
Article in European journal of nuclear medicine and molecular imaging, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 56 citations in OpenAlex.
- Pre-clinical SPECT and SPECT-CT in Oncology.Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer · 2026Review
- Development of a novel small-animal myocardial phantom can evaluate the image quality of dual-isotope simultaneous acquisition (DISA).Annals of nuclear medicine · 2022Article
- Performance evaluation of a preclinical SPECT/CT system for multi-animal and multi-isotope quantitative experiments.Scientific reports · 2022Article
- Performance evaluation of fifth-generation ultra-high-resolution SPECT system with two stationary detectors and multi-pinhole imaging.EJNMMI physics · 2020Article
- The clinical utilities of multi-pinhole single photon emission computed tomography.Quantitative imaging in medicine and surgery · 2020Review
- Monte Carlo study of x-ray detection configurations for benchtop x-ray fluorescence computed tomography of gold nanoparticle-loaded objects.Physics in medicine and biology · 2020Article
- A second-generation virtual-pinhole PET device for enhancing contrast recovery and improving lesion detectability of a whole-body PET/CT scanner.Medical physics · 2019Article
- Perspectives on Small Animal Radionuclide Imaging; Considerations and Advances in Atherosclerosis.Frontiers in medicine · 2019Review
- Multi-pinhole fluorescent x-ray computed tomography for molecular imaging.Scientific reports · 2017Article
- Dual-energy fluorescent x-ray computed tomography system with a pinhole design: Use of K-edge discontinuity for scatter correction.Scientific reports · 2017Article
- The role of preclinical SPECT in oncological and neurological research in combination with either CT or MRI.European journal of nuclear medicine and molecular imaging · 2014Review
- U-SPECT-BioFluo: an integrated radionuclide, bioluminescence, and fluorescence imaging platform.EJNMMI research · 2014Article
- Onboard functional and molecular imaging: a design investigation for robotic multipinhole SPECT.Medical physics · 2014Article
- Performance assessment of the single photon emission microscope: high spatial resolution SPECT imaging of small animal organs.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2013Article
- Performance evaluation of small-animal multipinhole μSPECT scanners for mouse imaging.European journal of nuclear medicine and molecular imaging · 2013Article
- Effects of attenuation map accuracy on attenuation-corrected micro-SPECT images.EJNMMI research · 2013Article
- The sodium iodide symporter (NIS) as an imaging reporter for gene, viral, and cell-based therapies.Current gene therapy · 2012Review
- The effects of object activity distribution on multiplexing multi-pinhole SPECT.Physics in medicine and biology · 2011Article
- Accurate Coregistration between Ultra-High-Resolution Micro-SPECT and Circular Cone-Beam Micro-CT Scanners.International journal of biomedical imaging · 2010Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeSmall-animal single photon emission computed tomography (SPECT) with focused multi-pinhole collimation geometries allows scanning modes in which large amounts of photons can be collected from specific volumes of interest. Here we present new tools that improve targeted imaging of specific organs and tumours, and validate the effects of improved targeting of the pinhole focus.
methodsA SPECT system with 75 pinholes and stationary detectors was used (U-SPECT-II). An XYZ stage automatically translates the animal bed with a specific sequence in order to scan a selected volume of interest. Prior to stepping the animal through the collimator, integrated webcams acquire images of the animal. Using sliders, the user designates the desired volume to be scanned (e.g. a xenograft or specific organ) on these optical images. Optionally projections of an atlas are overlaid semiautomatically to locate specific organs. In order to assess the effects of more targeted imaging, scans of a resolution phantom and a mouse myocardial phantom, as well as in vivo mouse cardiac and tumour scans, were acquired with increased levels of targeting. Differences were evaluated in terms of count yield, hot rod visibility and contrast-to-noise ratio.
resultsBy restricting focused SPECT scans to a 1.13-ml resolution phantom, count yield was increased by a factor 3.6, and visibility of small structures was significantly enhanced. At equal noise levels, the small-lesion contrast measured in the myocardial phantom was increased by 42%. Noise in in vivo images of a tumour and the mouse heart was significantly reduced.
conclusionTargeted pinhole SPECT improves images and can be used to shorten scan times. Scan planning with optical cameras provides an effective tool to exploit this principle without the necessity for additional X-ray CT imaging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.