ArticleIntensive care medicine2011
Comparison of patient-ventilator interfaces based on their computerized effective dead space.
Article in Intensive care medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed.
- Efficacy of Noninvasive Ventilation With Expiratory Washout in Stable COPD Patients.Respiratory care · 2025Trial
- Eccentric cycling for chronic respiratory disease: Does helmet ventilation add value? A randomized controlled trial.Chronic respiratory diseaseTrial
- Influence of leaks and mask design on COBMJ open respiratory research · 2026Observational
- Rebreathing during CPAP therapy and its implications in obstructive sleep apnea.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025Review
- Early prolonged prone position in noninvasively ventilated patients with SARS-CoV-2-related moderate-to-severe hypoxemic respiratory failure: clinical outcomes and mechanisms for treatment response in the PRO-NIV study.Critical care (London, England) · 2022Article
- The use of head helmets to deliver noninvasive ventilatory support: a comprehensive review of technical aspects and clinical findings.Critical care (London, England) · 2021Review
- Computational evaluation of rebreathing and effective dead space on a helmet-like interface during the COVID-19 pandemic.Journal of biomechanics · 2021Article
- ISCCM Guidelines for the Use of Non-invasive Ventilation in Acute Respiratory Failure in Adult ICUs.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2020Article
- Noninvasive Mechanical Ventilation in Acute Respiratory Failure Patients: A Respiratory Therapist Perspective.The open respiratory medicine journal · 2015Article
- Noninvasive ventilation in acute respiratory failure.International journal of chronic obstructive pulmonary disease · 2014Review
- Year in review in Intensive Care Medicine 2011: III. ARDS and ECMO, weaning, mechanical ventilation, noninvasive ventilation, pediatrics and miscellanea.Intensive care medicine · 2012Review
- From belief to knowledge: call it evidence if you prefer.Intensive care medicine · 2011Article
- Performance of ICU ventilators during noninvasive ventilation with large leaks in a total face mask: a bench study.Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e TisilogiaArticle
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeNon-invasive ventilation is largely used to treat acute and chronic respiratory failure. This ventilation encounters a non-negligible rate of failure related to the used interface/mask, but the reasons for this failure remain unclear. In order to shed light on this issue and to better understand the effects of the geometrical design of interfaces, we aimed to quantify flow, pressure and gas composition in terms of CO(2) and O(2) at the passage through different types of interface (oronasal mask, integral mask and helmet). In particular, we postulated that due to specific gas flow passing throughout the interface, the effective dead space added by the interface is not always related to the whole gas volume included in the interface.
methodsNumerical simulations, using computational fluid dynamics, were used to describe pressure, flow and gas composition during ventilation with the different interfaces.
resultsBetween the different interfaces the effective dead spaces differed only modestly (110-370 ml), whereas their internal volumes were markedly different (110-10,000 ml). Effective dead space was limited to half the tidal volume for the most voluminous interface, whereas it was close to the interface gas volume for the less voluminous interfaces. Pressure variations induced by the flow ventilation throughout the interface were negligible.
conclusionsEffective dead space is not related to the internal gas volume included in the interface, suggesting that this internal volume should not be considered as a limiting factor for their efficacy during non-invasive ventilation. Patient's comfort and synchrony have also to be taken into account.
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