ArticlePhysiological genomics2011
In silico QTL mapping of basal liver iron levels in inbred mouse strains.
Article in Physiological genomics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 18 citations in OpenAlex.
- Application of Cumulative Threshold Approaches to Tissue Iron Measurement on Histochemical or Synchrotron X‑ray Fluorescence Platforms.Chemical & biomedical imaging · 2026Article
- Acetyl-CoA Deficiency Is Involved in the Regulation of Iron Overload on Lipid Metabolism in Apolipoprotein E Knockout Mice.Molecules (Basel, Switzerland) · 2022Article
- High Iron Exposure from the Fetal Stage to Adulthood in Mice Alters Lipid Metabolism.Nutrients · 2022Article
- Revisiting hemochromatosis: geneticAnnals of translational medicine · 2021Review
- In silico mapping of quantitative trait loci (QTL) regulating the milk ionome in mice identifies a milk iron locus on chromosome 1.Mammalian genome : official journal of the International Mammalian Genome Society · 2018Article
- Article
- Brain iron accumulation affects myelin-related molecular systems implicated in a rare neurogenetic disease family with neuropsychiatric features.Molecular psychiatry · 2016Article
- Heritability of in vitro phenotypes exhibited by murine adipose-derived stromal cells.Mammalian genome : official journal of the International Mammalian Genome Society · 2016Article
- Gene co-expression networks shed light into diseases of brain iron accumulation.Neurobiology of disease · 2016Article
- A systems biology approach utilizing a mouse diversity panel identifies genetic differences influencing isoniazid-induced microvesicular steatosis.Toxicological sciences : an official journal of the Society of Toxicology · 2014Article
- Epistasis in iron metabolism: complex interactions between Cp, Mon1a, and Slc40a1 loci and tissue iron in mice.Mammalian genome : official journal of the International Mammalian Genome Society · 2013Article
- Fine-mapping and genetic analysis of the loci affecting hepatic iron overload in mice.PloS one · 2013Article
- In silico QTL mapping of maternal nurturing ability with the mouse diversity panel.Physiological genomics · 2012Article
- Systems genetic analysis of multivariate response to iron deficiency in mice.American journal of physiology. Regulatory, integrative and comparative physiology · 2012Article
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Authors and funding
9 authors at 4 institutions in 2 countries.
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Abstract
Both iron deficiency and iron excess are detrimental in many organisms, and previous studies in both mice and humans suggest that genetic variation may influence iron status in mammals. However, these genetic factors are not well defined. To address this issue, we measured basal liver iron levels in 18 inbred strains of mice of both sexes on a defined iron diet and found ∼4-fold variation in liver iron in males (lowest 153 μg/g, highest 661 μg/g) and ∼3-fold variation in females (lowest 222 μg/g, highest 658 μg/g). We carried out a genome-wide association mapping to identify haplotypes underlying differences in liver iron and three other related traits (copper and zinc liver levels, and plasma diferric transferrin levels) in a subset of 14 inbred strains for which genotype information was available. We identified two putative quantitative trait loci (QTL) that contain genes with a known role in iron metabolism: Eif2ak1 and Igf2r. We also identified four putative QTL that reside in previously identified iron-related QTL and 22 novel putative QTL. The most promising putative QTL include a 0.22 Mb region on Chromosome 7 and a 0.32 Mb region on Chromosome 11 that both contain only one candidate gene, Adam12 and Gria1, respectively. Identified putative QTL are good candidates for further refinement and subsequent functional studies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.