ArticleJournal of cell science2010
Ethanol sensitizes mitochondria to the permeability transition by inhibiting deacetylation of cyclophilin-D mediated by sirtuin-3.
Article in Journal of cell science, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 46 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 72 citations in OpenAlex.
- The role of ALDH2 in tumorigenesis and tumor progression: Targeting ALDH2 as a potential cancer treatment.Acta pharmaceutica Sinica. B · 2021Review
- Lapachol-Induced Upregulation of Sirt1/Sirt3 is linked with Improved Skin Wound Healing in Alloxan-induced Diabetic Mice.Iranian journal of pharmaceutical research : IJPR · 2021Article
- Effects of Sirt3‑autophagy and resveratrol activation on myocardial hypertrophy and energy metabolism.Molecular medicine reports · 2020Article
- Mitochondrial permeability transition in cardiac ischemia-reperfusion: whether cyclophilin D is a viable target for cardioprotection?Cellular and molecular life sciences : CMLS · 2017Review
- SIRT3 deficiency promotes lung fibrosis by augmenting alveolar epithelial cell mitochondrial DNA damage and apoptosis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2017Article
- Mitochondrial CaJournal of bioenergetics and biomembranes · 2017Review
- The Expression and Related Clinical Significance of SIRT3 in Non-Small-Cell Lung Cancer.Disease markers · 2017Article
- High Sensitivity of SIRT3 Deficient Hearts to Ischemia-Reperfusion Is Associated with Mitochondrial Abnormalities.Frontiers in pharmacology · 2017Article
- Article
- Alcoholic pancreatitis: New insights into the pathogenesis and treatment.World journal of gastrointestinal pathophysiology · 2016Review
- SIRT3 Deacetylates Ceramide Synthases: IMPLICATIONS FOR MITOCHONDRIAL DYSFUNCTION AND BRAIN INJURY.The Journal of biological chemistry · 2016Article
- Possible Role of Interaction between PPARα and Cyclophilin D in Cardioprotection of AMPK against In Vivo Ischemia-Reperfusion in Rats.PPAR research · 2016Article
- Activation of sirtuin 1/3 improves vascular hyporeactivity in severe hemorrhagic shock by alleviation of mitochondrial damage.Oncotarget · 2015Article
- Structural mechanisms of cyclophilin D-dependent control of the mitochondrial permeability transition pore.Biochimica et biophysica acta · 2015Review
- The Mitochondrial Permeability Transition Pore: Channel Formation by F-ATP Synthase, Integration in Signal Transduction, and Role in Pathophysiology.Physiological reviews · 2015Review
- The Role of Mitochondrial DNA in Mediating Alveolar Epithelial Cell Apoptosis and Pulmonary Fibrosis.International journal of molecular sciences · 2015Review
- Cell death disguised: The mitochondrial permeability transition pore as the c-subunit of the F(1)F(O) ATP synthase.Pharmacological research · 2015Review
- Sirtuin 1 signaling and alcoholic fatty liver disease.Hepatobiliary surgery and nutrition · 2015Review
- The beneficial effects of AMP kinase activation against oxidative stress are associated with prevention of PPARα-cyclophilin D interaction in cardiomyocytes.American journal of physiology. Heart and circulatory physiology · 2015Article
- The mitochondrial permeability transition pore: molecular nature and role as a target in cardioprotection.Journal of molecular and cellular cardiology · 2015Review
Corrections and comments
- Expression of concern · 2016-02-15Concerns/Issues about Image · Investigation by Company/Institution · Investigation by Journal/Publisher · Objections by Third Party · · This EoC is upgraded by PMID: 27369361, citing Misconduct by John G Pastorino;
- Retraction · 2016-07-01Duplication of/in Image · Falsification/Fabrication of Data · Investigation by Company/Institution · Investigation by Journal/Publisher · Investigation by ORI · Manipulation of Images · Misconduct - Official Investigation(s) and/or Finding(s) · Misconduct by Author · Objections by Third Party · Upgrade/Update of Prior Notice(s) · · Misconduct by John G Pastorino; Expression of Concern at PMID: 26905966;
- Commented on by
- Commented on by
- Expression of concern
- Retracted
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Ethanol increases the vulnerability of mitochondria to induction of the mitochondrial permeability transition (MPT). Cyclophilin-D activity enhances the potential for the permeability transition pore (PTP) to open. In the present study, we demonstrate that ethanol and its metabolism sensitize the PTP to opening, in part by increasing the acetylation and activity of cyclophilin-D. This effect of ethanol is mediated by inhibiting the activity of sirtuin-3, an NAD(+) dependent deacetylase that is localized to the mitochondrial matrix. The ethanol-enhanced acetylation of cyclophilin-D also increases the interaction of cyclophilin-D with the adenine nucleotide translocator-1 (ANT-1) and is dependent on ethanol metabolism. Moreover, activation of AMPK, a known positive modulator of sirtuin activity, prevented the ethanol-induced suppression of sirtuin-3 activity and the attendant increase of cyclophilin-D acetylation, activity and association with ANT-1. Additionally, AMPK reactivation of sirtuin-3 prevented the sensitization to the MPT and the enhancement of cell killing by TNF in cells exposed to ethanol.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.