ArticleDevelopment (Cambridge, England)2010
Characterisation of a new regulator of BDNF signalling, Sprouty3, involved in axonal morphogenesis in vivo.
Article in Development (Cambridge, England), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- A genome-wide association study implicates the BMP7 locus as a risk factor for nonsyndromic metopic craniosynostosis.Human genetics · 2020Pooled it
- Sprouty4 at the crossroads of Trk neurotrophin receptor signaling suppression by glucocorticoids.Frontiers in molecular neuroscience · 2023Article
- Aberrant early growth of individual trigeminal sensory and motor axons in a series of mouse genetic models of 22q11.2 deletion syndrome.Human molecular genetics · 2020Article
- Inherited duplication of the pseudoautosomal region Xq28 in a subject with Gilles de la Tourette syndrome and intellectual disability: a case report.Molecular cytogenetics · 2020Article
- Extracellular Vesicles of Human Periodontal Ligament Stem Cells Contain MicroRNAs Associated to Proto-Oncogenes: Implications in Cytokinesis.Frontiers in genetics · 2020Article
- Article
- Sprouty2-a Novel Therapeutic Target in the Nervous System?Molecular neurobiology · 2019Review
- Tropomyosin-Related Kinase B (TrkB) Regulates Neurite Outgrowth via a Novel Interaction with Suppressor of Cytokine Signalling 2 (SOCS2).Molecular neurobiology · 2019Article
- Opposite Expression Patterns ofFrontiers in psychiatry · 2019Article
- Identification ofGenetics · 2018Article
- Decoding the ubiquitous role of microRNAs in neurogenesis.Molecular neurobiology · 2017Review
- Negative feedback regulation of the ERK1/2 MAPK pathway.Cellular and molecular life sciences : CMLS · 2016Review
- SPRY1 regulates mammary epithelial morphogenesis by modulating EGFR-dependent stromal paracrine signaling and ECM remodeling.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Kalirin is required for BDNF-TrkB stimulated neurite outgrowth and branching.Neuropharmacology · 2016Article
- Ear manipulations reveal a critical period for survival and dendritic development at the single-cell level in Mauthner neurons.Developmental neurobiology · 2015Article
- The role of microRNAs in regulating neuronal connectivity.Frontiers in cellular neuroscience · 2014Review
- Modulation of fibroblast growth factor signaling is essential for mammary epithelial morphogenesis.PloS one · 2014Article
- PI3K regulates branch initiation and extension of cultured mammary epithelia via Akt and Rac1 respectively.Developmental biology · 2013Article
- Differential hippocampal gene expression is associated with climate-related natural variation in memory and the hippocampus in food-caching chickadees.Molecular ecology · 2013Article
- Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
During development, many organs, including the kidney, lung and mammary gland, need to branch in a regulated manner to be functional. Multicellular branching involves changes in cell shape, proliferation and migration. Axonal branching, however, is a unicellular process that is mediated by changes in cell shape alone and as such appears very different to multicellular branching. Sprouty (Spry) family members are well-characterised negative regulators of Receptor tyrosine kinase (RTK) signalling. Knockout of Spry1, 2 and 4 in mouse result in branching defects in different organs, indicating an important role of RTK signalling in controlling branching pattern. We report here that Spry3, a previously uncharacterised member of the Spry family plays a role in axonal branching. We found that spry3 is expressed specifically in the trigeminal nerve and in spinal motor and sensory neurons in a Brain-derived neurotrophin factor (BDNF)-dependent manner. Knockdown of Spry3 expression causes an excess of axonal branching in spinal cord motoneurons in vivo. Furthermore, Spry3 inhibits the ability of BDNF to induce filopodia in Xenopus spinal cord neurons. Biochemically, we show that Spry3 represses calcium release downstream of BDNF signalling. Altogether, we have found that Spry3 plays an important role in the regulation of axonal branching of motoneurons in vivo, raising the possibility of unexpected conservation in the involvement of intracellular regulators of RTK signalling in multicellular and unicellular branching.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.