ArticleNucleic acids research2011
Characterization of the relationship between integrase, excisionase and antirepressor activities associated with a superinfecting Shiga toxin encoding bacteriophage.
Article in Nucleic acids research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.
- Systematic Discovery of a New Catalogue of Tyrosine-Type Integrases in Bacterial Genomic Islands.Applied and environmental microbiology · 2023Pooled it
- Genomic characterization of antimicrobial resistance and virulence determinants inApplied and environmental microbiology · 2026Article
- A molecular inventory of the faecal microbiomes of 23 marsupial species.Microbial genomics · 2026Article
- The LuxO-OpaR quorum-sensing cascade differentially controls Vibriophage VP882 lysis-lysogeny decision making in liquid and on surfaces.PLoS genetics · 2024Article
- Bacteriophages: sustainable and effective solution for climate-resilient agriculture.Sustainable microbiology · 2024Review
- Recent Advances in Antibiotic-Free Markers; Novel Technologies to Enhance Safe Human Food Production in the World.Molecular biotechnology · 2023Review
- Characterization of Temperate LPS-Binding Bordetella avium Phages That Lack Superinfection Immunity.Microbiology spectrum · 2023Article
- Helper-embedded satellites from an integrase clade that repeatedly targets prophage late genes.NAR genomics and bioinformatics · 2023Article
- Characterization and genomic study of EJP2, a novel jumbo phage targeting antimicrobial resistantFrontiers in microbiology · 2023Article
- Biocontrol of bacterial wilt in tomato with a cocktail of lytic bacteriophages.Applied microbiology and biotechnology · 2022Article
- Isolation, characterization, molecular analysis and application of bacteriophage DW-EC to control Enterotoxigenic Escherichia coli on various foods.Scientific reports · 2022Article
- Insights into the genome architecture and evolution of Shiga toxin encoding bacteriophages of Escherichia coli.BMC genomics · 2021Article
- Spinal Cord Injury Changes the Structure and Functional Potential of Gut Bacterial and Viral Communities.mSystems · 2021Article
- Bacteriophages of Shiga Toxin-ProducingPathogens (Basel, Switzerland) · 2021Review
- Article
- IHF stabilizes pathogenicity island I of uropathogenic Escherichia coli strain 536 by attenuating integrase I promoter activity.Scientific reports · 2020Article
- Pathogenicity Factors of Genomic Islands in Intestinal and ExtraintestinalFrontiers in microbiology · 2020Review
- The Site-Specific Recombination System of theFrontiers in microbiology · 2020Article
- Evolution of BACON Domain Tandem Repeats in crAssphage and Novel Gut Bacteriophage Lineages.Viruses · 2019Article
- Expanding the Diversity ofViruses · 2019Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Shigatoxigenic Escherichia coli emerged as new food borne pathogens in the early 1980s, primarily driven by the dispersal of Shiga toxin-encoding lambdoid bacteriophages. At least some of these Stx phages display superinfection phenotypes, which differ significantly from lambda phage itself, driving through in situ recombination further phage evolution, increasing host range and potentially increasing the host's pathogenic profile. Here, increasing levels of Stx phage Φ24(B) integrase expression in multiple lysogen cultures are demonstrated along with apparently negligible repression of integrase expression by the cognate CI repressor. The Φ24(B) int transcription start site and promoter region were identified and found to differ from in silico predictions. The unidirectional activity of this integrase was determined in an in situ, inducible tri-partite reaction. This indicated that Φ24(B) must encode a novel directionality factor that is controlling excision events during prophage induction. This excisionase was subsequently identified and characterized through complementation experiments. In addition, the previous proposal that a putative antirepressor was responsible for the lack of immunity to superinfection through inactivation of CI has been revisited and a new hypothesis involving the role of this protein in promoting efficient induction of the Φ24(B) prophage is proposed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.