ReviewBriefings in functional genomics2010
The epigenomic interface between genome and environment in common complex diseases.
Review in Briefings in functional genomics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed.
- WMRE2030: integrating wearable devices, multi-omics, and artificial intelligence-driven real-time feedback into a daily-scale closed-loop framework for a new era of precision exercise.Frontiers in physiology · 2026Review
- From reference epigenomes to response epigenomes: a public-health case built on the developing brain.Frontiers in public health · 2026Article
- Epigenomic insights into common human disease pathology.Cellular and molecular life sciences : CMLS · 2024Review
- Quantifying simultaneous innovations in evolutionary medicine.Theory in biosciences = Theorie in den Biowissenschaften · 2020Article
- A survey of inter-individual variation in DNA methylation identifies environmentally responsive co-regulated networks of epigenetic variation in the human genome.PLoS genetics · 2018Article
- The role of genetics and genomics in clinical psychiatry.Dialogues in clinical neuroscience · 2018Review
- Transgenerational latent early-life associated regulation unites environment and genetics across generations.Epigenomics · 2016Article
- Methylation Microarray Studies Highlight PDGFA Expression as a Factor in Biliary Atresia.PloS one · 2016Article
- Gene-specific DNA methylation profiles and LINE-1 hypomethylation are associated with myocardial infarction risk.Clinical epigenetics · 2015Article
- The era of genomic medicine.Clinical medicine (London, England) · 2013Review
- The role for epigenetic modifications in pain and analgesia response.Nursing research and practice · 2013Review
- Cubic regression-based degree of correction predicts the performance of whole bisulfitome amplified DNA methylation analysis.Epigenetics · 2012Article
- Gene × environment interaction by a longitudinal epigenome-wide association study (LEWAS) overcomes limitations of genome-wide association study (GWAS).Epigenomics · 2012Article
- Prognostic value of aberrant hypermethylation in pleural effusion of lung adenocarcinoma.Cancer biology & therapy · 2012Article
- Epigenetics and the transition from acute to chronic pain.Pain medicine (Malden, Mass.) · 2012Review
- Epigenetic mechanisms in commonly occurring cancers.DNA and cell biology · 2012Review
- Genetics of immunological and inflammatory components in age-related macular degeneration.Ocular immunology and inflammation · 2012Review
- Epigenetics, epidemiology and mitochondrial DNA diseases.International journal of epidemiology · 2012Review
- Trans-generational effect of maternal lactation during pregnancy: a Holstein cow model.PloS one · 2012Article
- Epigenetics and microRNAs in preeclampsia.Clinical and experimental hypertension (New York, N.Y. : 1993) · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
The epigenome plays the pivotal role as interface between genome and environment. True genome-wide assessments of epigenetic marks, such as DNA methylation (methylomes) or chromatin modifications (chromatinomes), are now possible, either through high-throughput arrays or increasingly by second-generation DNA sequencing methods. The ability to collect these data at this level of resolution enables us to begin to be able to propose detailed questions, and interrogate this information, with regards to changes that occur due to development, lineage and tissue-specificity, and significantly those caused by environmental influence, such as ageing, stress, diet, hormones or toxins. Common complex traits are under variable levels of genetic influence and additionally epigenetic effect. The detection of pathological epigenetic alterations will reveal additional insights into their aetiology and how possible environmental modulation of this mechanism may occur. Due to the reversibility of these marks, the potential for sequence-specific targeted therapeutics exists. This review surveys recent epigenomic advances and their current and prospective application to the study of common diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.