ArticleVirology journal2010
In vitro inhibitory activity of Alpinia katsumadai extracts against influenza virus infection and hemagglutination.
Article in Virology journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
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- Identifying citrus limonoids as a potential fusion inhibitor of DENV-2 virus through its in silico study and FTIR analysis.In silico pharmacology · 2024Article
- Inactivation of plant and animal viruses by proanthocyanidins fromPlant biotechnology (Tokyo, Japan) · 2021Article
- An overview of the chemical composition and biological activities of essential oils fromRSC advances · 2021Review
- Biomedical Applications of Chinese Herb-Synthesized Silver Nanoparticles by Phytonanotechnology.Nanomaterials (Basel, Switzerland) · 2021Review
- Plants Metabolites: Possibility of Natural Therapeutics Against the COVID-19 Pandemic.Frontiers in medicine · 2020Review
- Antiviral activities of extremophilic actinomycetes extracts from Kazakhstan's unique ecosystems against influenza viruses and paramyxoviruses.Virology journal · 2019Article
- Antiviral potential of green synthesized silver nanoparticles ofInternational journal of nanomedicine · 2019Article
- Antiviral Activities of Mulberry (Evidence-based complementary and alternative medicine : eCAM · 2018Article
- Acyclic Triterpenoids from Alpinia katsumadai Inhibit IL-6-Induced STAT3 Activation.Molecules (Basel, Switzerland) · 2017Article
- Antiviral activity of phenanthrenes from the medicinal plant Bletilla striata against influenza A virus.BMC complementary and alternative medicine · 2017Article
- Anti-Influenza Virus (H5N1) Activity Screening on the Phloroglucinols from Rhizomes of Dryopteris crassirhizoma.Molecules (Basel, Switzerland) · 2017Article
- Interfering With Lipid Raft Association: A Mechanism to Control Influenza Virus Infection ByIranian journal of pharmaceutical research : IJPR · 2017Article
- [Antiviral activities against influenza virus (FM1) of bioactive fractions and representative compounds extracted from Banlangen (Radix Isatidis)].Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2016Article
- Modes of Antiviral Action of Chemical Portions and Constituents from Woad Root Extract against Influenza Virus A FM1.Evidence-based complementary and alternative medicine : eCAM · 2016Article
- A phage-displayed peptide recognizing porcine aminopeptidase N is a potent small molecule inhibitor of PEDV entry.Virology · 2014Article
- Amaryllidaceae alkaloids inhibit nuclear-to-cytoplasmic export of ribonucleoprotein (RNP) complex of highly pathogenic avian influenza virus H5N1.Influenza and other respiratory viruses · 2013Article
- Effects of cocktail of four local Malaysian medicinal plants (Phyllanthus spp.) against dengue virus 2.BMC complementary and alternative medicine · 2013Article
- Alpinia: the gold mine of future therapeutics.3 Biotech · 2013Article
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Authors and funding
9 authors.
Funding
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Abstract
backgroundAlpinia katsumadai (AK) extracts and fractions were tested for in vitro antiviral activities against influenza virus type A, specially human A/PR/8/34 (H1N1) and avian A/Chicken/Korea/MS96/96 (H9N2), by means of time-of-addition experiments; pre-treatment, simultaneous treatment, and post treatment.
resultsIn pre-treatment assay, the AK extracts and AK fractions did not show significant antiviral activity. During the simultaneous treatment assay, one AK extract and five AK fractions designated as AK-1 to AK-3, AK-5, AK-10, and AK-11 showed complete inhibition of virus infectivity against A/PR/8/34 (H1N1) and A/Chicken/Korea/MS96/96 (H9N2). The 50% effective inhibitory concentrations (EC₅₀) of these one AK extracts and five AK fractions with exception of the AK-9 were from 0.8 ± 1.4 to 16.4 ± 4.5 μg/mL against A/PR/8/34 (H1N1). The two AK extracts and three AK fractions had EC₅₀ values ranging from <0.39 ± 0.4 to 2.3 ± 3.6 μg/mL against A/Chicken/Korea/MS96/96 (H9N2). By the hemagglutination inhibition (HI) assay, the two AK extracts and five AK fractions completely inhibited viral adsorption onto chicken RBCs at less than 100 μg/mL against both A/PR/8/34 (H1N1) and A/Chicken/Korea/MS96/96 (H9N2). Interestingly, only AK-3 was found with inhibition for both viral attachment and viral replication after showing extended antiviral activity during the post treatment assay and quantitative real-time PCR.
conclusionsThese results suggest that AK extracts and fractions had strong anti-influenza virus activity that can inhibit viral attachment and/or viral replication, and may be used as viral prophylaxis.
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