ArticleBreast cancer research : BCR2010
A genome-wide association scan on estrogen receptor-negative breast cancer.
Article in Breast cancer research : BCR, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 3 citations in OpenAlex.
- A reanalysis of a genome-wide association study on breast cancer in Asian populations using the SG10K_Health reference panel for imputation: a multi-Centre case-control analysis.Human molecular genetics · 2026Article
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- Evaluation of significant genome-wide association studies risk - SNPs in young breast cancer patients.PloS one · 2019Article
- Inference of patient-specific subpathway activities reveals a functional signature associated with the prognosis of patients with breast cancer.Journal of cellular and molecular medicine · 2018Article
- Investigation of altered urinary metabolomic profiles of invasive ductal carcinoma of breast using targeted and untargeted approaches.Metabolomics : Official journal of the Metabolomic Society · 2018Article
- Previous GWAS hits in relation to young-onset breast cancer.Breast cancer research and treatment · 2017Article
- Genomic Disparities in Breast Cancer Among Latinas.Cancer control : journal of the Moffitt Cancer Center · 2016Article
- A study of the potential anticancer activity ofOncology letters · 2016Article
- The Combinational Polymorphisms of ORAI1 Gene Are Associated with Preventive Models of Breast Cancer in the Taiwanese.BioMed research international · 2015Article
- Genome-wide association study of breast cancer in Latinas identifies novel protective variants on 6q25.Nature communications · 2014Article
- Approaches to integrating germline and tumor genomic data in cancer research.Carcinogenesis · 2014Review
- How many etiological subtypes of breast cancer: two, three, four, or more?Journal of the National Cancer Institute · 2014Review
- A genome-wide association study of early-onset breast cancer identifies PFKM as a novel breast cancer gene and supports a common genetic spectrum for breast cancer at any age.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2014Article
- Significant overlap between human genome-wide association-study nominated breast cancer risk alleles and rat mammary cancer susceptibility loci.Breast cancer research : BCR · 2014Article
- Fine mapping of breast cancer genome-wide association studies loci in women of African ancestry identifies novel susceptibility markers.Carcinogenesis · 2013Article
- Germline variation in TP53 regulatory network genes associates with breast cancer survival and treatment outcome.International journal of cancer · 2013Article
- Article
- Centromere protein-A, an essential centromere protein, is a prognostic marker for relapse in estrogen receptor-positive breast cancer.Breast cancer research : BCR · 2012Article
- Identification of colorectal cancer related genes with mRMR and shortest path in protein-protein interaction network.PloS one · 2012Article
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Authors and funding
28 authors at 1 institution in 1 country.
Funding
Abstract
introductionBreast cancer is a heterogeneous disease and may be characterized on the basis of whether estrogen receptors (ER) are expressed in the tumour cells. ER status of breast cancer is important clinically, and is used both as a prognostic indicator and treatment predictor. In this study, we focused on identifying genetic markers associated with ER-negative breast cancer risk.
methodsWe conducted a genome-wide association analysis of 285,984 single nucleotide polymorphisms (SNPs) genotyped in 617 ER-negative breast cancer cases and 4,583 controls. We also conducted a genome-wide pathway analysis on the discovery dataset using permutation-based tests on pre-defined pathways. The extent of shared polygenic variation between ER-negative and ER-positive breast cancers was assessed by relating risk scores, derived using ER-positive breast cancer samples, to disease state in independent, ER-negative breast cancer cases.
resultsAssociation with ER-negative breast cancer was not validated for any of the five most strongly associated SNPs followed up in independent studies (1,011 ER-negative breast cancer cases, 7,604 controls). However, an excess of small P-values for SNPs with known regulatory functions in cancer-related pathways was found (global P = 0.052). We found no evidence to suggest that ER-negative breast cancer shares a polygenic basis to disease with ER-positive breast cancer.
conclusionsER-negative breast cancer is a distinct breast cancer subtype that merits independent analyses. Given the clinical importance of this phenotype and the likelihood that genetic effect sizes are small, greater sample sizes and further studies are required to understand the etiology of ER-negative breast cancers.
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