ArticleBMC plant biology2010
A candidate gene association study on muscat flavor in grapevine (Vitis vinifera L.).
Article in BMC plant biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.
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Who cites it
67 citing papers in PubMed.
- A Metabolome Atlas of Grape Biodiversity.Journal of agricultural and food chemistry · 2026Article
- GC-MS-Based Volatile Metabolomics and Quantitative Trait Locus Mapping of Aroma Components in 'Muscat Hamburg' Grape.Plants (Basel, Switzerland) · 2026Article
- QTL mapping for berry firmness and functional characterization of a prioritized candidate gene VvNAC83 in grape.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- An advanced genotyping tool to inspect grapevine variability: the AxiomFrontiers in plant science · 2026Article
- A multivariate Bayesian modeling strategy coupled with QTL analysis reveals genetic loci linking important sensory wine quality attributes with their corresponding wine aroma compounds.Frontiers in plant science · 2026Article
- Investigation of mechanisms underlying seedlessness in a Sangiovese somatic variant through comparative genomic and histological analyses.BMC plant biology · 2025Article
- Improving the Antioxidant Potential of Berry Crops Through Genomic Advances and Modern Agronomic and Breeding Tools.Biotech (Basel (Switzerland)) · 2025Review
- GWAS identifies a molecular marker cluster associated with monoterpenoids in grapes.Horticulture research · 2025Article
- Biosynthetic Machinery to Abiotic Stress-Driven Emission: Decoding Multilayer Regulation of Volatile Terpenoids in Plants.Antioxidants (Basel, Switzerland) · 2025Review
- Comprehensive aroma profiles and the underlying molecular mechanisms in six grape varieties with different flavors.Frontiers in plant science · 2025Article
- Integrated Transcriptomic and Metabolomic Analysis Revealed Abscisic Acid-Induced Regulation of Monoterpene Biosynthesis in Grape Berries.Plants (Basel, Switzerland) · 2024Article
- Transcriptomic and free monoterpene analyses of aroma reveal that isopentenyl diphosphate isomerase inhibits monoterpene biosynthesis in grape (Vitis vinifera L.).BMC plant biology · 2024Article
- Editing VvDXS1 for the creation of muscat flavour in Vitis vinifera cv. Scarlet Royal.Plant biotechnology journal · 2024Article
- Breeding new seedless table grapevines for a more sustainable viticulture in Mediterranean climate.Frontiers in plant science · 2024Article
- Dissecting the genetic architecture of root-related traits in a grafted wild Vitis berlandieri population for grapevine rootstock breeding.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2023Article
- Basic leucine zipper geneHorticulture research · 2023Article
- Grapevine mono- and sesquiterpenes: Genetics, metabolism, and ecophysiology.Frontiers in plant science · 2023Review
- Grapevine genome analysis demonstrates the role of gene copy number variation in the formation of monoterpenes.Frontiers in plant science · 2023Article
- Genetic architecture of berry aroma compounds in a QTL (quantitative trait loci) mapping population of interspecific hybrid grapes (Vitis labruscana × Vitis vinifera).BMC plant biology · 2022Article
- Monoterpenoids Evolution and MEP Pathway Gene Expression Profiles in Seven Table Grape Varieties.Plants (Basel, Switzerland) · 2022Article
7 more citing papers are in PubMed but not listed here.
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7 authors.
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Abstract
backgroundThe sweet, floral flavor typical of Muscat varieties (Muscats), due to high levels of monoterpenoids (geraniol, linalool and nerol), is highly distinct and has been greatly appreciated both in table grapes and in wine since ancient times. Muscat flavor determination in grape (Vitis vinifera L.) has up to now been studied by evaluating monoterpenoid levels through QTL analysis. These studies have revealed co-localization of 1-deoxy-D-xylulose 5-phosphate synthase (VvDXS) with the major QTL positioned on chromosome 5.
resultsWe resequenced VvDXS in an ad hoc association population of 148 grape varieties, which included muscat-flavored, aromatic and neutral accessions as well as muscat-like aromatic mutants and non-aromatic offsprings of Muscats. Gene nucleotide diversity and intragenic linkage disequilibrium (LD) were evaluated. Structured association analysis revealed three SNPs in moderate LD to be significantly associated with muscat-flavored varieties. We identified a putative causal SNP responsible for a predicted non-neutral substitution and we discuss its possible implications for flavor metabolism. Network analysis revealed a major star-shaped cluster of reconstructed haplotypes unique to muscat-flavored varieties. Moreover, muscat-like aromatic mutants displayed unique non-synonymous mutations near the mutated site of Muscat genotypes.
conclusionsThis study is a crucial step forward in understanding the genetic regulation of muscat flavor in grapevine and it also sheds light on the domestication history of Muscats. VvDXS appears to be a possible human-selected locus in grapevine domestication and post-domestication. The putative causal SNP identified in Muscat varieties as well as the unique mutations identifying the muscat-like aromatic mutants under study may be immediately applied in marker-assisted breeding programs aimed at enhancing fragrance and aroma complexity respectively in table grape and wine cultivars.
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