ArticleCritical care (London, England)2010
Differences in organ dysfunctions between neonates and older children: a prospective, observational, multicenter study.
Article in Critical care (London, England), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- Therapeutic effects and outcomes of rescue high-frequency oscillatory ventilation for premature infants with severe refractory respiratory failure.Scientific reports · 2021Trial
- Continuous renal replacement therapy in neonates with multiple organ dysfunction syndrome: clinical utilization effects and outcomes.Italian journal of pediatrics · 2025Article
- Health Care Resource Use and Costs After Hospitalization With Multiple Organ Dysfunction in Children.JAMA network open · 2025Article
- Traditional herbal medicine use doubled the risk of multi-organ dysfunction syndrome in children: A prospective cohort study.PloS one · 2024Article
- A nomogram to predict 28-day mortality in neonates with sepsis: a retrospective study based on the MIMIC-III database.Translational pediatrics · 2023Article
- Comparison of Three Different Multiple Organ Dysfunction Scores for Predicting Mortality after Neonatal Cardiac Surgery.Children (Basel, Switzerland) · 2023Article
- Article
- Gene expression signatures identify paediatric patients with multiple organ dysfunction who require advanced life support in the intensive care unit.EBioMedicine · 2020Article
- Clinician Accuracy in Identifying and Predicting Organ Dysfunction in Critically Ill Children.Critical care medicine · 2020Article
- [Clinical effect of continuous blood purification in treatment of multiple organ dysfunction syndrome in neonates].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2020Article
- Outcomes Associated With Multiple Organ Dysfunction Syndrome in Critically Ill Children With Hyperglycemia.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2019Article
- Drug Disposition and Pharmacotherapy in Neonatal ECMO: From Fragmented Data to Integrated Knowledge.Frontiers in pediatrics · 2019Review
- Epidemiology and Outcomes of Pediatric Multiple Organ Dysfunction Syndrome.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2017Review
- Strategic Planning for Research in Pediatric Critical Care.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2016Article
- Acute kidney injury: the dilemma of organ failures or just a circular reference?Critical care (London, England) · 2013Article
- Systematic Review and Meta-Analysis of Cardiovascular Medications in Neonatal Hypotension.Biomedicine hubArticle
- Multiple organ dysfunction syndrome in humans and animals.Journal of veterinary internal medicineReview
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe multiple organ dysfunction syndrome (MODS) is a major cause of death for patients admitted to pediatric intensive care units (PICU). The Pediatric Logistic Organ Dysfunction (PELOD) score has been validated in order to describe and quantify the severity of organ dysfunction (OD). There are several physiological differences between neonates and older children. The objective of the study was to determine whether there are differences in incidence of ODs and mortality rate between full-term neonates (age <28 days) and older children.
methodsIn a prospective, observational study, 1806 patients, admitted to seven PICUs between September 1998 and February 2000 were included. The PELOD score, which includes six organ dysfunctions and 12 variables, was recorded daily. For each variable, the most abnormal value was used to define the daily OD. For each OD, the most abnormal value each day and that during the entire stay were used in calculating the daily PELOD and PELOD scores, respectively. The relationships between OD, daily OD, PELOD, daily PELOD and mortality were compared between the two strata (neonates, older children) based on the discrimination power, logistic and multiple regression analyses.
resultsOf the 1806 enrolled patients 171 (9.5%) were neonates. Incidence of MODS and mortality rate were higher among neonates than in older children (14.6% vs. 5.5%, P < 10(-7); 75.4%, vs. 50.9%, P < 10(-4); respectively). Daily PELOD scores were significantly higher in neonates from day 1 to day 4. Daily cardiovascular, respiratory and renal dysfunction scores from day 1 to day 4 as well as the PELOD score for the entire pediatric intensive care unit stay were also significantly higher in neonates. Neurological, cardiovascular, and hepatic dysfunctions were independent predictors of death among neonates while all ODs significantly contributed to the risk of mortality in older children.
conclusionsOur data demonstrate that incidence of MODS and mortality rate are higher among neonates compared to older children. Neurological, cardiovascular, and hepatic dysfunctions were the only significant contributors to neonatal mortality. Stratification for neonates versus older children might be useful in clinical trials where MODS is considered as an outcome measure.
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