ArticleSleep2010
Dopaminergic regulation of sleep and cataplexy in a murine model of narcolepsy.
Article in Sleep, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed, 68 citations in OpenAlex.
- Production of Chitosan-PVA Coated Vitamin E and Ephedrine Nanoparticles Using Electrospraying for the Treatment of Narcolepsy.Molecules (Basel, Switzerland) · 2026Article
- Molecular Tools to Study and Control Dopaminergic Neurotransmission With Light.Medicinal research reviews · 2025Review
- Spotlight on Seniors with Narcolepsy: Comorbidities and Management.Journal of clinical medicine · 2025Article
- Wakefulness Induced by TAAR1 Partial Agonism in Mice Is Mediated Through Dopaminergic Neurotransmission.International journal of molecular sciences · 2024Article
- Wakefulness Induced by TAAR1 Partial Agonism is Mediated Through Dopaminergic Neurotransmission.bioRxiv : the preprint server for biology · 2024Article
- Insomnia-related rodent models in drug discovery.Acta pharmacologica Sinica · 2024Review
- A molecular network map of orexin-orexin receptor signaling system.Journal of cell communication and signaling · 2023Article
- Abnormal Regional Spontaneous Neural Activity and Functional Connectivity in Unmedicated Patients with Narcolepsy Type 1: A Resting-State fMRI Study.International journal of environmental research and public health · 2022Article
- Calcium, Magnesium, Potassium, and Sodium Oxybates Oral Solution: A Lower-Sodium Alternative for Cataplexy or Excessive Daytime Sleepiness Associated with Narcolepsy.Nature and science of sleep · 2022Review
- Sleep, Narcolepsy, and Sodium Oxybate.Current neuropharmacology · 2022Article
- A circuit perspective on narcolepsy.Sleep · 2020Article
- Dopamine DPsychopharmacology · 2019Article
- Neurobiological and immunogenetic aspects of narcolepsy: Implications for pharmacotherapy.Sleep medicine reviews · 2019Review
- Fluctuation of primary motor cortex excitability during cataplexy in narcolepsy.Annals of clinical and translational neurology · 2019Article
- The Orexin/Receptor System: Molecular Mechanism and Therapeutic Potential for Neurological Diseases.Frontiers in molecular neuroscience · 2018Review
- Trace Amine-Associated Receptor 1 Agonists as Narcolepsy Therapeutics.Biological psychiatry · 2017Article
- Challenges in the development of therapeutics for narcolepsy.Progress in neurobiology · 2017Review
- GABA Cells in the Central Nucleus of the Amygdala Promote Cataplexy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- VTA dopaminergic neurons regulate ethologically relevant sleep-wake behaviors.Nature neuroscience · 2016Article
- Nigrostriatal Dopamine Acting on Globus Pallidus Regulates Sleep.Cerebral cortex (New York, N.Y. : 1991) · 2016Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
STUDY
objectivesTo determine if the dopaminergic system modulates cataplexy, sleep attacks and sleep-wake behavior in narcoleptic mice.
designHypocretin/orexin knockout (i.e., narcoleptic) and wild-type mice were administered amphetamine and specific dopamine receptor modulators to determine their effects on sleep, cataplexy and sleep attacks. PATIENTS OR
participantsHypocretin knockout (n = 17) and wild-type mice (n = 21).
interventionsCataplexy, sleep attacks and sleep-wake behavior were identified using electroencephalogram, electromyogram and videography. These behaviors were monitored for 4 hours after an i.p. injection of saline, amphetamine and specific dopamine receptor modulators (D1- and D2-like receptor modulators). MEASUREMENTS AND
resultsAmphetamine (2 mg/kg), which increases brain dopamine levels, decreased sleep attacks and cataplexy by 61% and 67%, suggesting that dopamine transmission modulates such behaviors. Dopamine receptor modulation also had powerful effects on sleep attacks and cataplexy. Activation (SKF 38393; 20 mg/kg) and blockade (SCH 23390; 1 mg/kg) of D1-like receptors decreased and increased sleep attacks by 77% and 88%, without affecting cataplexy. Pharmacological activation of D2-like receptors (quinpirole; 0.5 mg/kg) increased cataplectic attacks by 172% and blockade of these receptors (eticlopride; 1 mg/kg) potently suppressed them by 97%. Manipulation of D2-like receptors did not affect sleep attacks.
conclusionsWe show that the dopaminergic system plays a role in regulating both cataplexy and sleep attacks in narcoleptic mice. We found that cataplexy is modulated by a D2-like receptor mechanism, whereas dopamine modulates sleep attacks by a D1-like receptor mechanism. These results support a role for the dopamine system in regulating sleep attacks and cataplexy in a murine model of narcolepsy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.