ArticleSleep2010
Hypocretin and GABA interact in the pontine reticular formation to increase wakefulness.
Article in Sleep, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 30 citations in OpenAlex.
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- The potential role of the orexin system in premenstrual syndrome.Frontiers in endocrinology · 2023Review
- Escape From Oblivion: Neural Mechanisms of Emergence From General Anesthesia.Anesthesia and analgesia · 2019Review
- Resuscitation therapy for traumatic brain injury-induced coma in rats: mechanisms of median nerve electrical stimulation.Neural regeneration research · 2015Article
- Understanding how discrete populations of hypothalamic neurons orchestrate complicated behavioral states.Frontiers in systems neuroscience · 2015Review
- GABAergic transmission in rat pontine reticular formation regulates the induction phase of anesthesia and modulates hyperalgesia caused by sleep deprivation.The European journal of neuroscience · 2014Article
- The hypocretins (orexins) mediate the "phasic" components of REM sleep: A new hypothesis.Sleep science (Sao Paulo, Brazil) · 2014Article
- Article
- Sleep and Anesthesia Interactions: A Pharmacological Appraisal.Current anesthesiology reports · 2013Article
- Hypocretinergic and non-hypocretinergic projections from the hypothalamus to the REM sleep executive area of the pons.Brain research · 2013Article
- Neuropharmacology of Sleep and Wakefulness: 2012 Update.Sleep medicine clinics · 2012Article
- Sleep duration varies as a function of glutamate and GABA in rat pontine reticular formation.Journal of neurochemistry · 2011Article
- Hypocretin and its emerging role as a target for treatment of sleep disorders.Current neurology and neuroscience reports · 2011Review
- Endogenous GABA levels in the pontine reticular formation are greater during wakefulness than during rapid eye movement sleep.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Neuropharmacology of Sleep and Wakefulness.Sleep medicine clinics · 2010Article
- GABA(A) receptors in the pontine reticular formation of C57BL/6J mouse modulate neurochemical, electrographic, and behavioral phenotypes of wakefulness.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
STUDY
objectivesHypocretin-1/orexin A administered directly into the oral part of rat pontine reticular formation (PnO) causes an increase in wakefulness and extracellular gamma-aminobutyric acid (GABA) levels. The receptors in the PnO that mediate these effects have not been identified. Therefore, this study tested the hypothesis that the increase in wakefulness caused by administration of hypocretin-1 into the PnO occurs via activation of GABAA receptors and hypocretin receptors.
designWithin/between subjects.
settingUniversity of Michigan. PATIENTS OR
participantsTwenty-three adult male Crl:CD*(SD) (Sprague Dawley) rats.
interventionsMicroinjection of hypocretin-1, bicuculline (GABAA receptor antagonist), SB-334867 (hypocretin receptor-1 antagonist), and Ringer solution (vehicle control) into the PnO. MEASUREMENTS AND
resultsHypocretin-1 caused a significant concentration-dependent increase in wakefulness and decrease in rapid eye movement (REM) sleep and non-REM (NREM) sleep. Coadministration of SB-334867 and hypocretin-1 blocked the hypocretin-1-induced increase in wakefulness and decrease in both the NREM and REM phases of sleep. Coadministration of bicuculline and hypocretin-1 blocked the hypocretin-1-induced increase in wakefulness and decrease in NREM sleep caused by hypocretin-1.
conclusionThe increase in wakefulness caused by administering hypocretin-1 to the PnO is mediated by hypocretin receptors and GABAA receptors in the PnO. These results show for the first time that hypocretinergic and GABAergic transmission in the PnO can interact to promote wakefulness.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.