ArticleEuropean journal of immunology2010
Critical role for IL-21 in both primary and memory anti-viral CD8+ T-cell responses.
Article in European journal of immunology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
44 citing papers in PubMed, 53 citations in OpenAlex.
- Interleukin-21 responses in patients with chronic hepatitis B.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2015Trial
- IL-21 isoform transgenic mice spontaneously develop mammary tumors: possible involvement of IL-21-induced osteopontin expression in tumorigenesis.Frontiers in immunology · 2026Article
- T-cell receptor/CD28-targeted immunotherapeutics selectively drive naive T-cell expansion to generate functional HIV-specific responses.Journal of virology · 2025Article
- T cells in health and disease.Signal transduction and targeted therapy · 2023Review
- Interleukin-21 in Viral Infections.International journal of molecular sciences · 2021Review
- Review
- TargetingFrontiers in immunology · 2021Article
- Association between Interleukin-21, 23 and 27 Expression and Protein Level with Cytomegalovirus Infection in Liver Transplant Recipients.International journal of organ transplantation medicine · 2020Article
- Respiratory syncytial virus reduces STAT3 phosphorylation in human memory CD8 T cells stimulated with IL-21.Scientific reports · 2019Article
- IL-21 regulates SOCS1 expression in autoreactive CD8Scientific reports · 2019Article
- Article
- IL-21 Selectively Protects CD62LJournal of immunology (Baltimore, Md. : 1950) · 2018Article
- IL-21 Therapy Controls Immune Activation and Maintains Antiviral CD8AIDS research and human retroviruses · 2017Article
- [Correlation between viral load and expression of programmed death-1 on the surface of T follicular helper cells in patients with chronic hepatitis C].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2017Article
- Interleukin-7 in Patients With Chronic Hepatitis B May Have Effect on T Follicular Helper Cells and Specific Cellular Immunity.Hepatitis monthly · 2016Article
- IL-21 and T Cell Differentiation: Consider the Context.Trends in immunology · 2016Review
- A Context-Dependent Role for IL-21 in Modulating the Differentiation, Distribution, and Abundance of Effector and Memory CD8 T Cell Subsets.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- IL-21 Is Important for Induction of KLRG1+ Effector CD8 T Cells during Acute Intracellular Infection.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Interleukin-21 combined with ART reduces inflammation and viral reservoir in SIV-infected macaques.The Journal of clinical investigation · 2015Article
- Th17 and Th17/Treg ratio at early HIV infection associate with protective HIV-specific CD8(+) T-cell responses and disease progression.Scientific reports · 2015Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
While it is well established that CD8(+) T cells generated in the absence of CD4(+) T cells mediate defective recall responses, the mechanism by which CD4(+) T cells confer help in the generation of CD8(+) T-cell responses remains poorly understood. To determine whether CD4(+) T-cell-derived IL-21 is an important regulator of CD8(+) T-cell responses in help-dependent and -independent viral infections, we examined these responses in the IL-21Rα(-/-) mouse model. We show that IL-21 has a role in primary CD8(+) T-cell responses and in recall CD8(+) T-cell responses in help-dependent viral infections. This effect is due to a direct action of IL-21 in enhancing the proliferation of virus-specific CD8(+) T cells and reducing their TRAIL expression. These findings indicate that IL-21 is an important mediator of CD4(+) T-cell help to CD8(+) T cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.