Evidence map›Paper›PMID 21061175›Full record

ArticleFamilial cancer2011

Gene expression in response to ionizing radiation and family history of gastric cancer.

Francesca Marcon, Francesco Silvestrini, Ester Siniscalchi, Domenico Palli, Calogero Saieva, Riccardo Crebelli

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Article in Familial cancer, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Francesca MarconDepartment of Environment and Primary Prevention, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161, Rome, Italy. francesca.marcon@iss.it.
Francesco SilvestriniDepartment of Infectious, Parasitic and Immune-Mediated Diseases, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161, Rome, Italy.
Ester SiniscalchiDepartment of Environment and Primary Prevention, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161, Rome, Italy.
Domenico PalliMolecular and Nutritional Epidemiology Unit, ISPO-Cancer Prevention and Research Institute, Via Cosimo il Vecchio 2, 50139, Florence, Italy.
Calogero SaievaMolecular and Nutritional Epidemiology Unit, ISPO-Cancer Prevention and Research Institute, Via Cosimo il Vecchio 2, 50139, Florence, Italy.
Riccardo CrebelliDepartment of Environment and Primary Prevention, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Genes and molecular pathways involved in familial clustering of gastric cancer have not yet been identified. The purpose of the present study was to investigate gene expression changes in response to a cellular stress, and its link with a positive family history for this neoplasia. To this aim leukocytes of healthy first-degree relatives of gastric cancer patients and controls were challenged in vitro with ionizing radiation and gene expression evaluated 4 h later on microarrays with 1,800 cancer-related genes. Eight genes, mainly involved in signal transduction and cell cycle regulation, were differentially expressed in healthy relatives of gastric cancer cases. Functional class scoring by Gene Ontology classification highlighted two G-protein related pathways, implicated in the proliferation of neoplastic tissue, which were differentially expressed in healthy subjects with positive family history of gastric cancer. The relative expression of 84 genes related to these pathways was examined using the SYBR green-based quantitative real-time PCR. The results confirmed the indication of an involvement of G-protein coupled receptor pathways in GC familiarity provided by microarray analysis. This study indicates a possible association between familiarity for gastric cancer and altered transcriptional response to ionizing radiation.

Indexed as

Gene Expression ProfilingRadiation, IonizingAgedCase-Control StudiesCell Line, TumorFamily HealthFemaleGene Expression RegulationGene Expression Regulation, NeoplasticHumansLeukocytesMaleMiddle AgedOligonucleotide Array Sequence AnalysisStomach NeoplasmsBlood cellsFamilialGastric cancerGene expressionHereditaryIonising radiation

Identifiers

PMID21061175

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.