SynthesisFamilial cancer2011
Association between monoallelic MUTYH mutation and colorectal cancer risk: a meta-regression analysis.
Synthesis in Familial cancer, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.
- Familial gastric cancer: guidelines for diagnosis, treatment and periodic surveillance.Familial cancer · 2012Guideline
- Intra-Axial Cerebral Schwannoma in a Child: A Case Report.Neurology international · 2026Article
- Colorectal Cancer Screening in Hereditary and Familial High-Risk Populations: Best Practices and Future Directions.International journal of cancer · 2026Review
- Consideration for Multigene Panel Testing Outside of Cancer-Specific Genetic Testing.Oncology nursing forum · 2025Article
- Carrier Frequency and Incidence ofAnnals of laboratory medicine · 2025Article
- A comprehensive characterization of the spectrum of MUTYH germline pathogenic variants in Latin America.Familial cancer · 2024Article
- Monoallelic deleterious MUTYH mutations generate colorectal cancer: A case report.Clinical case reports · 2023Article
- Synchronous Neoplasia Rates at Colonoscopic Diagnosis of Early-Onset vs Average-Onset Colorectal Cancer.JAMA network open · 2023Article
- Monoallelic MUTYH pathogenic variants ascertained via multi-gene hereditary cancer panels are not associated with colorectal, endometrial, or breast cancer.Familial cancer · 2022Article
- Genetic evaluation of patients and families with concern for hereditary endocrine tumor syndromes.Familial cancer · 2022Article
- Evaluation of Classic, Attenuated, and Oligopolyposis of the Colon.Gastrointestinal endoscopy clinics of North America · 2022Review
- The context-specific role of germline pathogenicity in tumorigenesis.Nature genetics · 2021Article
- A multicenter study assessing the prevalence of germline genetic alterations in Chinese gastric-cancer patients.Gastroenterology report · 2021Article
- Characterizing germline APC and MUTYH variants in Ashkenazi Jews compared to other individuals.Familial cancer · 2021Article
- Review
- A Novel Mutation inOncoTargets and therapy · 2020Article
- Genetic testing for hereditary gastrointestinal cancer syndromes: Interpreting results in today's practice.Current treatment options in gastroenterology · 2019Review
- Association of a New Germline Variant in the MUTYH DNA Glycosylase Gene with Colorectal Adenoma Transformation into MalignancyIranian biomedical journal · 2019Article
- Response to Yang et al.Genetics in medicine : official journal of the American College of Medical Genetics · 2019Article
- Multi-gene panel testing confirms phenotypic variability in MUTYH-Associated Polyposis.Familial cancer · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Whether people who inherit a mutation in MUTYH from only one parent (monoallelic mutation) are at increased risk of colorectal cancer (CRC) remains controversial. Most previous studies and meta-analyses have not found statistically significant associations but, given carriers are relatively rare, may be underpowered to detect small increased risks. We have conducted a systematic review and meta-regression analysis of previously published case-control studies to estimate the strength of association for monoallelic MUTYH mutation and CRC risk. Potential sources of heterogeneity were evaluated. We have compared the carrier frequency in cases with a family history of CRC to that of controls, as a novel and powerful design, to measure statistical evidence of an association but not the strength of association. The magnitude of the genotype-disease association, estimated from a pooled odds ratio comparing cases unselected for family history with controls, was 1.15 (95% CI = 0.98-1.36) and not substantially altered by adjustment for potential sources of heterogeneity. Monoallelic mutation carrier frequency was greater for cases ascertained due to a family history (3.3%; SE 0.9%) than for controls (1.4%; SE 0.3%) (P = 0.02). Monoallelic MUTYH mutation carriers are at increased risk of CRC but the average increase is small.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.