Evidence map›Paper›PMID 21061172›Full record

ArticleFamilial cancer2011

Strictly defined familial male breast cancer.

Uwe Güth, Dieter Müller, Dorothy Jane Huang, Ellen Obermann, Hansjakob Müller

Abstract readCase Reports
PubMed Publisher
In one paragraph

Article in Familial cancer, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Uwe GüthDivision of Gynecologic Oncology, Department of Gynecology and Obstetrics, University Hospital Basel (UHB), Basel, Switzerland. ugueth@uhbs.ch
Dieter Müller
Dorothy Jane Huang
Ellen Obermann
Hansjakob Müller
University Hospital of Basel · CHUniversity of Basel · CHHess (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The term "familial male breast cancer" is often misleading, because in the breast cancer families reported in the literature, the vast majority of the patients were women and only a few were men. In this report, we present the rare case of a strictly defined familial male breast cancer (MBC) in which exclusively men were diagnosed with breast cancer. Three of four brothers developed the disease between the age of 46 and 64 years within a period of 21 years whereas all female relatives remained unaffected. The three affected men did not show the typical known clinical and genetic risk factors for MBC. An X-linked recessive inheritance may be possible in these cases. One way to potentially improve the identification of the causes of MBC could be a through a strictly studying families in which the male members were exclusively diagnosed with this malignancy. This approach emphasizes familial MBC as a distinct entity and not only as a variant of female breast cancer.

Indexed as

Genetic Predisposition to DiseaseBRCA1 ProteinBRCA2 ProteinBreast Neoplasms, MaleCarcinoma, Ductal, BreastFemaleFrameshift MutationGenetic TestingHumansMaleMiddle AgedPedigreePhenotypeRisk FactorsBRCA1 ProteinBRCA1 protein, humanBRCA2 ProteinBRCA2 protein, human

Identifiers

PMID21061172
OpenAlexW1984738767

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.