ArticleCellular and molecular neurobiology2011
The Wnt signaling pathway protects retinal ganglion cell 5 (RGC-5) cells from elevated pressure.
Article in Cellular and molecular neurobiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 34 citations in OpenAlex.
- Wnt/β-Catenin Signaling Pathway Is Strongly Implicated in Cadmium-Induced Developmental Neurotoxicity and Neuroinflammation: Clues from Zebrafish Neurobehavior and In Vivo Neuroimaging.International journal of molecular sciences · 2022Article
- The neuroprotective role of Wnt signaling in the retina.Neural regeneration research · 2021Article
- The Role of Small Molecules and Their Effect on the Molecular Mechanisms of Early Retinal Organoid Development.International journal of molecular sciences · 2021Review
- Emerging model systems and treatment approaches for Leber's hereditary optic neuropathy: Challenges and opportunities.Biochimica et biophysica acta. Molecular basis of disease · 2020Review
- Proteome alterations in aqueous humour of primary open angle glaucoma patients.International journal of ophthalmology · 2020Article
- Wnt Signaling in vascular eye diseases.Progress in retinal and eye research · 2019Review
- Wnt Signaling Protects against Paclitaxel-Induced Spiral Ganglion Neuron Damage in the Mouse CochleaBioMed research international · 2019Article
- Inhibition on Apoptosis Induced by Elevated Hydrostatic Pressure in Retinal Ganglion Cell-5 via Laminin Upregulating β1-integrin/Focal Adhesion Kinase/Protein Kinase B Signaling Pathway.Chinese medical journal · 2016Article
- Wnt activation protects against neomycin-induced hair cell damage in the mouse cochlea.Cell death & disease · 2016Article
- Activation of Wnt/β-catenin signaling in Muller glia protects photoreceptors in a mouse model of inherited retinal degeneration.Neuropharmacology · 2015Article
- Induction of Neuronal Morphology in the 661W Cone Photoreceptor Cell Line with Staurosporine.PloS one · 2015Article
- Wnts in adult brain: from synaptic plasticity to cognitive deficiencies.Frontiers in cellular neuroscience · 2013Review
- Differential neuronal expression of receptor interacting protein 3 in rat retina: involvement in ischemic stress response.BMC neuroscience · 2013Article
- Muller glia in retinal innate immunity: a perspective on their roles in endophthalmitis.Critical reviews in immunology · 2013Review
- Expression of brain-derived neurotrophic factor is regulated by the Wnt signaling pathway.Neuroreport · 2012Article
- The Wnt/β-catenin pathway cross-talks with STAT3 signaling to regulate survival of retinal pigment epithelium cells.PloS one · 2012Article
- Article
- Curcumin attenuates staurosporine-mediated death of retinal ganglion cells.Investigative ophthalmology & visual science · 2011Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The Wnt pathway is an essential signaling cascade that regulates survival and differentiation in the retina. We recently demonstrated that retinal ganglion cells (RGCs) have constitutively active Wnt signaling in vivo. However, the role of Wnt in RGC viability or function is unknown. In this study, we investigated whether Wnt protects the retinal ganglion cell line RGC-5 from elevated pressure, oxidative stress, and hypoxia injuries. Expression of RGC marker genes in the RGC-5 cultures was confirmed by immunocytochemistry and PCR. We demonstrated that the Wnt3a ligand significantly reduced pressure-induced caspase activity in RGC-5 cells (n = 5, P = 0.03) and decreased the number of TUNEL-positive cells (n = 5, P = 0.0014). Notably, Wnt3a-dependent protection was reversed by the Wnt signaling inhibitor Dkk1. In contrast, Wnt3a did not protect RGC-5 cells from oxidative stress or hypoxia. Furthermore, Wnt3a significantly increased growth factor expression in the presence of elevated pressure but not in the presence of oxidative stress and hypoxia. These results indicate that Wnt3a induces injury-specific survival pathways in RGC-5 cells, potentially by upregulating neuroprotective growth factors. Therefore, activation of the Wnt pathway by Wnt3a could be investigated further as a tool to develop novel molecular therapeutic strategies for the prevention of RGC death in retinal disease.
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