ArticleCellular and molecular neurobiology2011
Localization of prohibitin in the nuclear matrix and alteration of its expression during differentiation of human neuroblastoma SK-N-SH cells induced by retinoic acid.
Article in Cellular and molecular neurobiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
- A Current State of Proteomics in Adult and Pediatric Inflammatory Bowel Diseases: A Systematic Search and Review.International journal of molecular sciences · 2023Review
- Prohibitin promotes de-differentiation and is a potential therapeutic target in neuroblastoma.JCI insight · 2019Article
- Significance of prohibitin domain family in tumorigenesis and its implication in cancer diagnosis and treatment.Cell death & disease · 2018Review
- β-catenin induces expression of prohibitin gene in acute leukemic cells.Oncology reports · 2017Article
- Multifunctional Envelope-Type siRNA Delivery Nanoparticle Platform for Prostate Cancer Therapy.ACS nano · 2017Article
- Prohibitin confers cytoprotection against ISO-induced hypertrophy in H9c2 cells via attenuation of oxidative stress and modulation of Akt/Gsk-3β signaling.Molecular and cellular biochemistry · 2017Article
- Multifaceted role of prohibitin in cell survival and apoptosis.Apoptosis : an international journal on programmed cell death · 2015Review
- Association of prohibitin-1 and 2 with oxidative stress in rats with renal interstitial fibrosis.Molecular biology reports · 2014Article
- Dynamic change of Prohibitin2 expression in rat sciatic nerve after crush.Cellular and molecular neurobiology · 2013Article
- Prohibitin ligands in cell death and survival: mode of action and therapeutic potential.Chemistry & biology · 2013Review
- Immunoproteomic to identify antigens in the intestinal mucosa of Crohn's disease patients.PloS one · 2013Article
- All-trans retinoic acid treatment is associated with prohibitin expression in renal interstitial fibrosis rats.International journal of molecular sciences · 2012Article
- Less expression of prohibitin is associated with increased paired box 2 (PAX2) in renal interstitial fibrosis rats.International journal of molecular sciences · 2012Article
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The nuclear matrix-intermediate filament system of human neuroblastoma SK-N-SH cells before and after retinoic acid (RA) treatment was selectively extracted and the distribution of prohibitin (PHB) in the nuclear matrix, as well as its colocalization with related genes, was observed. Results of two-dimensional gel electrophoresis (2-DE), mass spectrometry (MS) identification, and protein immunoblotting all confirm that PHB was present in the components of SK-N-SH nuclear matrix proteins and was down-regulated after RA treatment. Immunofluorescence microscopy observations show that PHB was localized in the nuclear matrix and its distribution was altered due to RA treatment. Laser confocal microscopy results reveal that PHB colocalized with the expression products of c-myc, c-fos, p53, and Rb, but the colocalization region was altered after RA treatment. Our results prove that PHB is a nuclear matrix protein and is localized in nuclear matrix fibers. The distribution of PHB in SK-N-SH cells and its colocalization with related proto-oncogenes and tumor suppressor genes suggest that PHB plays pivotal roles in the differentiation of SK-N-SH cells and deserves further study.
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