ArticleEuropean journal of epidemiology2010
Heart failure and the risk of stroke: the Rotterdam Study.
Article in European journal of epidemiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04696120 (Effects of APIXaban on BRAIN Protection in Patients With Sinus Rhythm and Heart Failure), which is not on this map. Cited by 51 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of APIXaban on BRAIN Protection in Patients With Sinus Rhythm and Heart Failure: APIXBRAIN-HF Trial
Who cites it
51 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Development of a high-performing, cost-effective and inclusive Afrocentric predictive model for stroke: a meta-analysis approach.BMC neurology · 2025Pooled it
- Antiplatelet versus anticoagulation treatment for people with heart failure in sinus rhythm.The Cochrane database of systematic reviews · 2025Pooled it
- Prevalence and incidence of stroke, white matter hyperintensities, and silent brain infarcts in patients with chronic heart failure: A systematic review, meta-analysis, and meta-regression.Frontiers in cardiovascular medicine · 2022Pooled it
- The Dilemma in the Management of Patients with Heart Failure with Reduced Ejection Fraction, Sinus Rhythm and Left Ventricular Spontaneous Echo Contrast: A Narrative Review.Current cardiology reviews · 2026Review
- Heart failure, dementia is associated with increased stroke severity, in-hospital mortality and complications.ESC heart failure · 2025Article
- JCS/JHRS 2024 Guideline Focused Update on Management of Cardiac Arrhythmias.Journal of arrhythmia · 2025Article
- Association of cataract surgery with stroke among older adults in the United States.Eye (London, England) · 2025Article
- Polygenic risk scores for atrial fibrillation and heart failure and the risk of stroke and dementia.Brain communications · 2025Article
- Prognoses and risk stratification of thrombus-associated events in heart failure patients without atrial fibrillation.ESC heart failure · 2024Article
- Preexisting Heart Disease Spectrum and In-Hospital Outcomes for Patients With Acute Ischemic Stroke.Stroke (Hoboken, N.J.) · 2024Article
- Incident stroke in individuals with peripartum cardiomyopathy.American heart journal · 2024Article
- Early stroke after left ventricular assist device implantation: role of right heart failure.Journal of thoracic disease · 2023Article
- Duration of Heightened Risk of Acute Ischemic Stroke After Hospitalization for Acute Systolic Heart Failure.Journal of the American Heart Association · 2023Article
- Left Ventricular Ejection Fraction Can Predict Atrial Thrombosis Even in Non-High-Risk Individuals with Atrial Fibrillation.Journal of clinical medicine · 2022Article
- Neurological Manifestations of Myocarditis.Current neurology and neuroscience reports · 2022Review
- The burden of cardiovascular outcomes in heart failure patients with new-onset, prevalent, and without type 2 diabetes.Clinical research in cardiology : official journal of the German Cardiac Society · 2022Article
- Mendelian Randomization Study of Heart Failure and Stroke Subtypes.Frontiers in cardiovascular medicine · 2022Article
- Ischemic Stroke in Acute Decompensated Heart Failure: From the KCHF Registry.Journal of the American Heart Association · 2021Article
- Ischemic Stroke and Heart Failure: Facts and Numbers. An Update.Journal of clinical medicine · 2021Review
- Risk of stroke in patients with heart failure and sinus rhythm: data from the Swedish Heart Failure Registry.ESC heart failure · 2021Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Patients with heart failure used to have an increased risk of stroke, but this may have changed with current treatment regimens. We assessed the association between heart failure and the risk of stroke in a population-based cohort that was followed since 1990. The study uses the cohort of the Rotterdam Study and is based on 7,546 participants who at baseline (1990–1993) were aged 55 years or over and free from stroke. The associations between heart failure and risk of stroke were assessed using time-dependent Cox proportional hazards models, adjusted for cardiovascular risk factors (smoking, diabetes mellitus, BMI, ankle brachial index, blood pressure, atrial fibrillation, myocardial infarction and relevant medication). At baseline, 233 participants had heart failure. During an average follow-up time of 9.7 years, 1,014 persons developed heart failure, and 827 strokes (470 ischemic, 75 hemorrhagic, 282 unclassified) occurred. The risk of ischemic stroke was more than five-fold increased in the first month after diagnosis of heart failure (age and sex adjusted HR 5.79, 95% CI 2.15–15.62), but attenuated over time (age and sex adjusted HR 3.50 [95% CI 1.96–6.25] after 1–6 months and 0.83 [95% CI 0.53–1.29] after 0.5–6 years). Additional adjustment for cardiovascular risk factors only marginally attenuated these risks. In conclusion, the risk of ischemic stroke is strongly increased shortly after the diagnosis of heart failure but returns to normal within 6 months after onset of heart failure.
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