ReviewInternational journal of legal medicine2011
State-of-the-art of bone marrow analysis in forensic toxicology: a review.
Review in International journal of legal medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 73 citations in OpenAlex.
- Unlocking the potential of bone marrow in postmortem forensic toxicology: current evidence and future perspectives.Journal of analytical toxicology · 2026Review
- Assessment of cardiac biomarker "point-of-care" testing as postmortem diagnostic tool.International journal of legal medicine · 2025Article
- Cytoplasmic changes in bone marrow cells as indicators of postmortem interval.F1000Research · 2025Article
- Estimation of postmortem interval using histological and oxidative biomarkers in human bone marrow.Forensic science, medicine, and pathology · 2024Article
- Pentobarbital intoxication as a potential underlying cause for electrocution in a bearded vulture.Veterinary research communications · 2023Article
- Postmortem Analysis of Opioids and Metabolites in Skeletal Tissue.Journal of analytical toxicology · 2022Article
- The DI-SPME Method for Determination of Selected Narcotics and Their Metabolites, and Application to Bone Marrow and Whole Blood Analysis.Molecules (Basel, Switzerland) · 2022Article
- Developments in high-resolution mass spectrometric analyses of new psychoactive substances.Archives of toxicology · 2022Review
- Homicidal poisoning series in a nursing home: retrospective toxicological investigations in bone marrow and hair.International journal of legal medicine · 2022Article
- Alternative matrices in forensic toxicology: a critical review.Forensic toxicology · 2022Review
- Sample preparation of bone tissue for MALDI-MSI for forensic and (pre)clinical applications.Analytical and bioanalytical chemistry · 2021Article
- Detecting drugs in dry bone: a pilot study of skeletal remains with a post-mortem interval over 23 years.International journal of legal medicine · 2021Article
- Guidelines for Collection of Biological Samples for Clinical and Forensic Toxicological Analysis.Forensic sciences research · 2016Article
- Using bone marrow matrix to analyze meprobamate for forensic toxicological purposes.International journal of legal medicine · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although blood is the reference medium in the field of forensic toxicology, alternative matrices are required in case of limited, unavailable or unusable blood samples. The present review investigated the suitability of bone marrow (BM) as an alternative matrix to characterize xenobiotic consumption and its influence on the occurrence of death. Basic data on BM physiology are reported in order to highlight the specificities of this matrix and their analytical and toxicokinetic consequences. A review of case reports, animal and human studies involving BM sample analysis focuses on the various parameters of interpretation of toxicological results: analytic limits, sampling location, pharmacokinetics, blood/BM concentration correlation, stability and postmortem redistribution. Tables summarizing the analytical conditions and quantification of 45 compounds from BM samples provide a useful tool for toxicologists. A specific section devoted to ethanol shows that, despite successful quantification, interpretation is highly dependent on postmortem interval. In conclusion, BM is an interesting alternative matrix, and further experimental data and validated assays are required to confirm its great potential relevance in forensic toxicology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.