ReviewThe review of diabetic studies : RDS2010
Bone marrow-derived stem cell transplantation for the treatment of insulin-dependent diabetes.
Review in The review of diabetic studies : RDS, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 45 citations in OpenAlex.
- Estrogen versus bone marrow mesenchymal stromal cells in the regeneration of the parotid gland in ovariectomized rats.Journal of applied oral science : revista FOB · 2025Article
- Delivery of therapeutic agents and cells to pancreatic islets: Towards a new era in the treatment of diabetes.Molecular aspects of medicine · 2022Review
- Therapeutic Benefits of Mesenchymal Stem Cells in Acute Respiratory Distress Syndrome: Potential Mechanisms and Challenges.Journal of inflammation research · 2022Review
- Efficacy of Autologous Bone Marrow Mononuclear Cell Transplantation Therapy for Type 2 Diabetes Mellitus: An Updated Meta-Analysis.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2019Article
- Adipose stem cells from chronic pancreatitis patients improve mouse and human islet survival and function.Stem cell research & therapy · 2017Article
- Basic Fibroblast Growth Factor Inhibits Apoptosis and Promotes Proliferation of Adipose-Derived Mesenchymal Stromal Cells Isolated from Patients with Type 2 Diabetes by Reducing Cellular Oxidative Stress.Oxidative medicine and cellular longevity · 2017Article
- Re-engineering islet cell transplantation.Pharmacological research · 2015Review
- Mesenchymal stem cells in the treatment of type 1 diabetes mellitus.Endocrine pathology · 2015Review
- Bone marrow-derived mesenchymal stem cells for the treatment of heart failure.Heart failure reviews · 2015Review
- Karyotype stability of human umbilical cord-derived mesenchymal stem cells duringExperimental and therapeutic medicine · 2014Article
- Transdisciplinary approach to restore pancreatic islet function.Immunologic research · 2013Review
- B6.g7 mice reconstituted with BDC2·5 non-obese diabetic (BDC2·5NOD) stem cells do not develop autoimmune diabetes.Clinical and experimental immunology · 2013Article
- Article
- Harnessing the immunomodulatory and tissue repair properties of mesenchymal stem cells to restore β cell function.Current diabetes reports · 2012Review
- Unsaturated fatty acids induce mesenchymal stem cells to increase secretion of angiogenic mediators.Journal of cellular physiology · 2012Article
- Mesenchymal stem cells for the treatment of diabetes.Diabetes · 2012Article
- Moving from the laboratory bench to patients' bedside: considerations for effective therapy with stem cells.Clinical and translational science · 2011Review
- Potential clinical applications of adult human mesenchymal stem cell (Prochymal®) therapy.Stem cells and cloning : advances and applications · 2011Review
- Mesenchymal Stromal Cells as a Therapeutic Strategy to Support Islet Transplantation in Type 1 Diabetes Mellitus.Cell medicine · 2011Article
- The quest for tissue stem cells in the pancreas and other organs, and their application in beta-cell replacement.The review of diabetic studies : RDS · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The bone marrow is an invaluable source of adult pluripotent stem cells, as it gives rise to hematopoietic stem cells, endothelial progenitor cells, and mesenchymal cells, amongst others. The use of bone marrow-derived stem cell (BMC) transplantation (BMT) may be of assistance in achieving tissue repair and regeneration, as well as in modulating immune responses in the context of autoimmunity and transplantation. Ongoing clinical trials are evaluating the effects of BMC to preserve functional beta-cell mass in subjects with type 1 and type 2 diabetes, and to favor engraftment and survival of transplanted islets. Additional trials are evaluating the impact of BMT (i.e., mesenchymal stem cells) on the progression of diabetes complications. This article reviews the progress in the field of BMC for the treatment of subjects with insulin-dependent diabetes, and summarizes clinical data of pilot studies performed over the last two decades at our research center by combining allogeneic islet transplantation with donor-specific BMC. Clinical data is summarized from pilot studies performed at our research center over the last two decades.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.