ReviewThe review of diabetic studies : RDS2010
Adult pancreatic alpha-cells: a new source of cells for beta-cell regeneration.
Review in The review of diabetic studies : RDS, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Relationships between type 2 diabetes, cell dysfunction, and redox signaling: A meta-analysis of single-cell gene expression of human pancreatic α- and β-cells.Journal of diabetes · 2022Pooled it
- High plasma glutamate and low glutamine-to-glutamate ratio are associated with type 2 diabetes: Case-cohort study within the PREDIMED trial.Nutrition, metabolism, and cardiovascular diseases : NMCD · 2019Article
- Effect of Age on Diabetogenicity of Alloxan in Ossabaw Miniature Swine.Comparative medicine · 2019Article
- The Central Role of Glucokinase in Glucose Homeostasis: A Perspective 50 Years After Demonstrating the Presence of the Enzyme in Islets of Langerhans.Frontiers in physiology · 2019Review
- Insulin acts as a repressive factor to inhibit the ability of PAR2 to induce islet cell transdifferentiation.Islets · 2018Article
- Oral application of a periodontal pathogen impacts SerpinE1 expression and pancreatic islet architecture in prediabetes.Journal of periodontal research · 2017Article
- PAR2 regulates regeneration, transdifferentiation, and death.Cell death & disease · 2016Article
- A synopsis of factors regulating beta cell development and beta cell mass.Cellular and molecular life sciences : CMLS · 2016Review
- Metabolic and pancreatic effects of bone marrow mesenchymal stem cells transplantation in mice fed high-fat diet.PloS one · 2015Article
- Pharmacological induction of pancreatic islet cell transdifferentiation: relevance to type I diabetes.Cell death & disease · 2014Article
- Transgenic pigs with pancreas-specific expression of green fluorescent protein.The Journal of reproduction and development · 2014Article
- MicroRNAs as pharmacological targets in diabetes.Pharmacological research · 2013Review
- Generation of beta cells from human pluripotent stem cells: Potential for regenerative medicine.Seminars in cell & developmental biology · 2012Review
- Development and regeneration in the endocrine pancreas.ISRN endocrinology · 2012Article
- IL-7 uniquely maintains FoxP3(+) adaptive Treg cells that reverse diabetes in NOD mice via integrin-β7-dependent localization.Journal of autoimmunity · 2011Article
- β-Cell Generation: Can Rodent Studies Be Translated to Humans?Journal of transplantation · 2011Article
- The quest for tissue stem cells in the pancreas and other organs, and their application in beta-cell replacement.The review of diabetic studies : RDS · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Beta-cell deficit is the major pathological feature in type 1 and type 2 diabetes patients, and plays a key role in disease progression. In principle, beta-cell regeneration can occur by replication of pre-existing beta-cells, or by beta-cell neogenesis from stem/progenitors. Unfortunately, beta-cell replication is limited by the almost complete absence of beta-cells in patients with type 1 diabetes, and the increasing recognition that the beta-cell replicative capacity declines severely with age. Therefore, beta-cell neogenesis has received increasing interest. Many different cell types within the pancreas have been suggested as potential beta-cell stem/progenitor cells, but the data have been conflicting. In some cases, this may be due to different regeneration models. On the other hand, different results have been obtained with similar regeneration models, leading to confusion about the nature and existence of beta-cell neogenesis in adult animals. Here, we review the major candidates for adult regeneration pathways, and focus on the recent discovery that alpha-cells can function as a novel beta-cell progenitor. Of note, this is a pathway that appears to be unique to beta-cell neogenesis in the adult, as the embryonic pathway of beta-cell neogenesis does not proceed through a glucagon-positive intermediate. We conclude that beta-cell neogenesis from alpha-cells is a new pathway of potential therapeutic significance, making it of high importance to elucidate the molecular events in alpha- to beta-cell conversion.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.