ArticlePloS one2010
Identification of candidate genes for dyslexia susceptibility on chromosome 18.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 22 papers, 2 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Common variants in left/right asymmetry genes and pathways are associated with relative hand skill.PLoS genetics · 2013Pooled it
- Language and reading impairments are associated with increased prevalence of non-right-handedness.Child developmentPooled it
- Toward an Improved Understanding of Dyslexia: Reflections on a New Consensus Definition and Its Implications.Dyslexia (Chichester, England) · 2026Article
- Specific Learning Disorders: Variation Analysis of 15 Candidate Genes in 9 Multiplex Families.Medicina (Kaunas, Lithuania) · 2023Article
- A rare missense variant in the ATP2C2 gene is associated with language impairment and related measures.Human molecular genetics · 2021Article
- The Polygenic Nature and Complex Genetic Architecture of Specific Learning Disorder.Brain sciences · 2021Review
- Genome-wide association scan identifies new variants associated with a cognitive predictor of dyslexia.Translational psychiatry · 2019Article
- The DCDC2 deletion is not a risk factor for dyslexia.Translational psychiatry · 2017Article
- [Research advances in susceptible genes for developmental dyslexia in children].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2016Review
- Nedd4-2 haploinsufficiency causes hyperactivity and increased sensitivity to inflammatory stimuli.Scientific reports · 2016Article
- The handedness-associated PCSK6 locus spans an intronic promoter regulating novel transcripts.Human molecular genetics · 2016Article
- Further evidence for a parent-of-origin effect at the NOP9 locus on language-related phenotypes.Journal of neurodevelopmental disorders · 2016Article
- Dyslexia: the Role of Vision and Visual Attention.Current developmental disorders reports · 2014Review
- Genetic insights into the functional elements of language.Human genetics · 2013Review
- The effects of Kiaa0319 knockdown on cortical and subcortical anatomy in male rats.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2013Article
- Knockdown of the candidate dyslexia susceptibility gene homolog dyx1c1 in rodents: effects on auditory processing, visual attention, and cortical and thalamic anatomy.Developmental neuroscience · 2013Article
- Neocortical disruption and behavioral impairments in rats following in utero RNAi of candidate dyslexia risk gene Kiaa0319.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2012Article
- Developmental dyslexia.Lancet (London, England) · 2012Review
- The genetics of reading disabilities: from phenotypes to candidate genes.Frontiers in psychology · 2012Article
- The dyslexia candidate locus on 2p12 is associated with general cognitive ability and white matter structure.PloS one · 2012Article
Corrections and comments
- Erratum issuedRichardson, Alex J [added]
Authors and funding
12 authors.
Funding
Abstract
backgroundSix independent studies have identified linkage to chromosome 18 for developmental dyslexia or general reading ability. Until now, no candidate genes have been identified to explain this linkage. Here, we set out to identify the gene(s) conferring susceptibility by a two stage strategy of linkage and association analysis. METHODOLOGY/PRINCIPAL
findingsLinkage analysis: 264 UK families and 155 US families each containing at least one child diagnosed with dyslexia were genotyped with a dense set of microsatellite markers on chromosome 18. Association analysis: Using a discovery sample of 187 UK families, nearly 3000 SNPs were genotyped across the chromosome 18 dyslexia susceptibility candidate region. Following association analysis, the top ranking SNPs were then genotyped in the remaining samples. The linkage analysis revealed a broad signal that spans approximately 40 Mb from 18p11.2 to 18q12.2. Following the association analysis and subsequent replication attempts, we observed consistent association with the same SNPs in three genes; melanocortin 5 receptor (MC5R), dymeclin (DYM) and neural precursor cell expressed, developmentally down-regulated 4-like (NEDD4L).
conclusionsAlong with already published biological evidence, MC5R, DYM and NEDD4L make attractive candidates for dyslexia susceptibility genes. However, further replication and functional studies are still required.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.