ArticlePloS one2010
Antioxidant biomarkers from Vanda coerulea stems reduce irradiated HaCaT PGE-2 production as a result of COX-2 inhibition.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
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- Laccase-Catalyzed Biotransformation of Dihydrostilbenes and Phenanthrenes: A Route to Novel Natural Product Derivatives.ACS omega · 2026Article
- Therapeutic Potential and Predictive Pharmaceutical Modeling of Stilbenes inPharmaceutics · 2023Review
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- Ethnobotany, Phytochemistry, Biological Activities, and Health-Promoting Effects of the GenusEvidence-based complementary and alternative medicine : eCAM · 2022Review
- Gigantol Improves Cholesterol Metabolism and Progesterone Biosynthesis in MA-10 Leydig Cells.Current issues in molecular biology · 2021Article
- Gigantol inhibits cell proliferation and induces apoptosis by regulating DEK in non-small cell lung cancer.Experimental and therapeutic medicine · 2021Article
- Dihydrophenanthrenes from medicinal plants of Orchidaceae: A review.Chinese herbal medicines · 2021Review
- Three Novel Biphenanthrene Derivatives and a New Phenylpropanoid Ester fromPlants (Basel, Switzerland) · 2021Article
- Four Novel Phenanthrene Derivatives withMolecules (Basel, Switzerland) · 2021Article
- Antioxidant Effects and Potential Molecular Mechanism of Action ofFrontiers in veterinary science · 2021Article
- Acetylcholinesterase Inhibitory and Antioxidant Activity of the Compounds Isolated fromAdvances in pharmacological and pharmaceutical sciences · 2021Article
- Cypripedin, a phenanthrenequinone from Dendrobium densiflorum, sensitizes non-small cell lung cancer H460 cells to cisplatin-mediated apoptosis.Journal of natural medicines · 2018Article
- Gigantol inhibits Wnt/β-catenin signaling and exhibits anticancer activity in breast cancer cells.BMC complementary and alternative medicine · 2018Article
- Two New Stilbenoids from the Aerial Parts of Arundina graminifolia (Orchidaceae).Molecules (Basel, Switzerland) · 2016Article
- Chemical Constituents from the Aerial Parts of Cyrtopodium paniculatum.Molecules (Basel, Switzerland) · 2016Article
- Vanda roxburghii chloroform extract as a potential source of polyphenols with antioxidant and cholinesterase inhibitory activities: identification of a strong phenolic antioxidant.BMC complementary and alternative medicine · 2015Article
- Synthesis and Biological Evaluation of Novel Gigantol Derivatives as Potential Agents in Prevention of Diabetic Cataract.PloS one · 2015Article
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3 authors.
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Abstract
backgroundIn our investigations towards the isolation of potentially biologically active constituents from Orchidaceae, we carried out phytochemical and biological analyses of Vanda species. A preliminary biological screening revealed that Vanda coerulea (Griff. ex. Lindl) crude hydro-alcoholic stem extract displayed the best DPPH /(•)OH radical scavenging activity and in vitro inhibition of type 2 prostaglandin (PGE-2) release from UV(B) (60 mJ/cm(2)) irradiated HaCaT keratinocytes. PRINCIPAL
findingsBio-guided fractionation and phytochemical analysis led to the isolation of five stilbenoids: imbricatin (1) methoxycoelonin (2) gigantol (3) flavidin (4) and coelonin (5). Stilbenoids (1-3) were the most concentrated in crude hydro-alcoholic stem extract and were considered as Vanda coerulea stem biomarkers. Dihydro-phenanthropyran (1) and dihydro-phenanthrene (2) displayed the best DPPH/(•)OH radical scavenging activities as well as HaCaT intracellular antioxidant properties (using DCFH-DA probe: IC(50) 8.8 µM and 9.4 µM, respectively) compared to bibenzyle (3) (IC(50) 20.6 µM). In turn, the latter showed a constant inhibition of PGE-2 production, stronger than stilbenoids (1) and (2) (IC(50) 12.2 µM and 19.3 µM, respectively). Western blot analysis revealed that stilbenoids (1-3) inhibited COX-2 expression at 23 µM. Interestingly, stilbenoids (1) and (2) but not (3) were able to inhibit human recombinant COX-2 activity.
conclusionsMajor antioxidant stilbenoids (1-3) from Vanda coerulea stems displayed an inhibition of UV(B)-induced COX-2 expression. Imbricatin (1) and methoxycoelonin (2) were also able to inhibit COX-2 activity in a concentration-dependent manner thereby reducing PGE-2 production from irradiated HaCaT cells. Our studies suggest that stilbenoids (1-3) could be potentially used for skin protection against the damage caused by UV(B) exposure.
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