ArticlePloS one2010
Balanced dopamine is critical for pattern completion during associative memory recall.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Dopamine Enhances Item Novelty Detection via Hippocampal and Associative Recall via Left Lateral Prefrontal Cortex Mechanisms.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Trial
- The Ins and Outs of Dopamine Transporter Gene Manipulation: In Vivo Models of DAT Dysfunction.Advances in neurobiology · 2025Review
- Low-Affinity/High-Selectivity Dopamine Transport Inhibition Sufficient to Rescue Cognitive Functions in the Aging Rat.Biomolecules · 2023Article
- Effects of Intra-BLA Administration of PPAR Antagonists on Formalin-Evoked Nociceptive Behaviour, Fear-Conditioned Analgesia, and Conditioned Fear in the Presence or Absence of Nociceptive Tone in Rats.Molecules (Basel, Switzerland) · 2022Article
- Effect of Whey-Derived Lactopeptide β-Lactolin on Memory in Healthy Adults: An Integrated Analysis of Data from Randomized Controlled Trials.The journal of nutrition, health & aging · 2022Article
- A touchscreen-based paradigm to measure visual pattern separation and pattern completion in mice.Frontiers in neuroscience · 2022Article
- Behavioral pattern separation and its link to the neural mechanisms of fear generalization.Social cognitive and affective neuroscience · 2017Article
- Trial-by-Trial Modulation of Associative Memory Formation by Reward Prediction Error and Reward Anticipation as Revealed by a Biologically Plausible Computational Model.Frontiers in human neuroscience · 2017Article
- A behavioral defect of temporal association memory in mice that partly lack dopamine reuptake transporter.Scientific reports · 2015Article
- Bidirectional plasticity of cortical pattern recognition and behavioral sensory acuity.Nature neuroscience · 2011Article
- NMDA receptors are not required for pattern completion during associative memory recall.PloS one · 2011Article
- Photoperiodic suppression of drug reinstatement.Neuroscience · 2011Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Pattern completion, the ability to retrieve complete memories initiated by partial cues, is a critical feature of the memory process. However, little is known regarding the molecular and cellular mechanisms underlying this process. To study the role of dopamine in memory recall, we have analyzed dopamine transporter heterozygous knockout mice (DAT(+/-)), and found that while these mice possess normal learning, consolidation, and memory recall under full cue conditions, they exhibit specific deficits in pattern completion under partial cue condition. This form of memory recall deficit in the dopamine transporter heterozygous knockout mice can be reversed by a low dose of the dopamine antagonist haloperidol, further confirming that the inability to retrieve memory patterns is a result of dopamine imbalance. Therefore, our results reveal that a delicate control of the brain's dopamine level is critical for pattern completion during associative memory recall.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.