ArticlePloS one2010
Evidence of a louse-borne outbreak involving typhus in Douai, 1710-1712 during the war of Spanish succession.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed.
- Historic and Prehistoric Epidemics: An Overview of Sources Available for the Study of Ancient Pathogens.Epidemiologia (Basel, Switzerland) · 2022Review
- Ancient dental pulp: Masterpiece tissue for paleomicrobiology.Molecular genetics & genomic medicine · 2020Review
- Five millennia of Bartonella quintana bacteraemia.PloS one · 2020Article
- Genetic diversity of human head lice and molecular detection of associated bacterial pathogens in Democratic Republic of Congo.Parasites & vectors · 2019Article
- Report of the human body louse (Pediculus humanus) from clothes sold in a market in central Italy.Parasites & vectors · 2019Article
- Genomic blueprint of a relapsing fever pathogen in 15th century Scandinavia.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Detection of bacterial pathogens in clade E head lice collected from Niger's refugees in Algeria.Parasites & vectors · 2018Article
- RETRACTED: Body lice of homeless people reveal the presence of several emerging bacterial pathogens in northern Algeria.PLoS neglected tropical diseases · 2018Article
- Paleoproteomics of the Dental Pulp: The plague paradigm.PloS one · 2017Article
- Detection of bacterial pathogens including potential new species in human head lice from Mali.PloS one · 2017Article
- Head Lice of Pygmies Reveal the Presence of Relapsing Fever Borreliae in the Republic of Congo.PLoS neglected tropical diseases · 2016Article
- High Ancient Genetic Diversity of Human Lice, Pediculus humanus, from Israel Reveals New Insights into the Origin of Clade B Lice.PloS one · 2016Article
- False positives complicate ancient pathogen identifications using high-throughput shotgun sequencing.BMC research notes · 2014Article
- Plague epidemics and lice, Democratic Republic of the Congo.Emerging infectious diseases · 2013Article
- Strategy for sensitive and specific detection of Yersinia pestis in skeletons of the black death pandemic.PloS one · 2013Article
- Heat degradation of eukaryotic and bacterial DNA: an experimental model for paleomicrobiology.BMC research notes · 2012Article
- Article
- High throughput, multiplexed pathogen detection authenticates plague waves in medieval Venice, Italy.PloS one · 2011Article
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6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundThe new field of paleomicrobiology allows past outbreaks to be identified by testing dental pulp of human remains with PCR.
methodsWe identified a mass grave in Douai, France dating from the early XVIII(th) century. This city was besieged during the European war of Spanish succession. We tested dental pulp from 1192 teeth (including 40 from Douai) by quantitative PCR (qPCR) for R. prowazekii and B. quintana. We also used ultra-sensitive suicide PCR to detect R. prowazekii and genotyped positive samples. RESULTS AND DISCUSSION: In the Douai remains, we identified one case of B. quintana infection (by qPCR) and R. prowazekii (by suicide PCR) in 6/21 individuals (29%). The R. prowazekii was genotype B, a genotype previously found in a Spanish isolate obtained in the first part of the XX(th) century.
conclusionLouse-borne outbreaks were raging during the XVIII(th) century; our results support the hypothesis that typhus was imported into Europe by Spanish soldiers from America.
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