ArticlePloS one2010
Epistasis among Drosophila persimilis factors conferring hybrid male sterility with D. pseudoobscura bogotana.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed.
- Review
- Genetic basis to hybrid inviability is more complex than hybrid male sterility in Caenorhabditis nematodes.Heredity · 2018Article
- Pervasive antagonistic interactions among hybrid incompatibility loci.PLoS genetics · 2017Article
- Neighboring genes for DNA-binding proteins rescue male sterility in Drosophila hybrids.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Interspecific tests of allelism reveal the evolutionary timing and pattern of accumulation of reproductive isolation mutations.PLoS genetics · 2014Article
- The adaptive potential of hybridization demonstrated with bacteriophages.Journal of molecular evolution · 2013Article
- Genomic impacts of chromosomal inversions in parapatric Drosophila species.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2012Article
- Article
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Authors and funding
3 authors.
Funding
Abstract
The Bateson-Dobzhansky-Muller model posits that hybrid incompatibilities result from genetic changes that accumulate during population divergence. Indeed, much effort in recent years has been devoted to identifying genes associated with hybrid incompatibilities, often with limited success, suggesting that hybrid sterility and inviability are frequently caused by complex interactions between multiple loci and not by single or a small number of gene pairs. Our previous study showed that the nature of epistasis between sterility-conferring QTL in the Drosophila persimilis-D. pseudoobscura bogotana species pair is highly specific. Here, we further dissect one of the three QTL underlying hybrid male sterility between these species and provide evidence for multiple factors within this QTL. This result indicates that the number of loci thought to contribute to hybrid dysfunction may have been underestimated, and we discuss how linkage and complex epistasis may be characteristic of the genetics of hybrid incompatibilities. We further pinpoint the location of one locus that confers hybrid male sterility when homozygous, dubbed "mule-like", to roughly 250 kilobases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.