ArticlePloS one2010
A systems biology strategy on differential gene expression data discloses some biological features of atrial fibrillation.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- A multivariate statistical test for differential expression analysis.Scientific reports · 2022Article
- Integrative Analysis of Incongruous Cancer Genomics and Proteomics Datasets.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Insight into atrial fibrillation through analysis of the coding transcriptome in humans.Biophysical reviews · 2020Review
- A pre-existing population of ZEB2Journal of experimental & clinical cancer research : CR · 2020Article
- Article
- Somatic polyploidy is associated with the upregulation of c-MYC interacting genes and EMT-like signature.Oncotarget · 2016Article
- Response, use and habituation to a mouse house in C57BL/6J and BALB/c mice.Experimental animals · 2015Article
- Analysis on differential gene expression data for prediction of new biological features in permanent atrial fibrillation.PloS one · 2013Article
- Finding Self-organization from the Dynamic Gene Expressions of Innate Immune Responses.Frontiers in physiology · 2012Article
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Authors and funding
4 authors.
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Abstract
Atrial fibrillation (AF), the most common cardiac arrhythmia, is associated with extensive structural, contractile, and electrophysiological remodeling. In this manuscript we re-analyzed gene expression data from a microarray experiment on AF patients and control tissues, using a new paradigm based on a posteriori unsupervised strategy in which the discrimination of patients comes out from purely syntactical premises. This paradigm, more adherent to biological reality where genes work in highly connected networks, allowed us to get both a very precise patients/control discrimination and the discovery of cell adhesion/tissue modeling and inflammation processes as the main dimensions of AF.
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