ArticlePloS one2010
Determinants of glycan receptor specificity of H2N2 influenza A virus hemagglutinin.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 42 citations in OpenAlex.
- Dual receptor-binding, infectivity, and transmissibility of an emerging H2N2 low pathogenicity avian influenza virus.Nature communications · 2024Article
- Evolution of human H3N2 influenza virus receptor specificity has substantially expanded the receptor-binding domain site.Cell host & microbe · 2024Article
- A Review on Microbial Species for Forensic Body Fluid Identification in Healthy and Diseased Humans.Current microbiology · 2023Review
- Engineering an Optimal Y280-Lineage H9N2 Vaccine Strain by Tuning PB2 Activity.International journal of molecular sciences · 2023Article
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- Glycan-binding preferences and genetic evolution of human seasonal influenza A(H3N2) viruses during 1999-2007 in Taiwan.PloS one · 2018Article
- The Interplay between the Host Receptor and Influenza Virus Hemagglutinin and Neuraminidase.International journal of molecular sciences · 2017Review
- Assessment of transmission, pathogenesis and adaptation of H2 subtype influenza viruses in ferrets.Virology · 2015Article
- Glycan receptor specificity as a useful tool for characterization and surveillance of influenza A virus.Trends in microbiology · 2014Review
- Shotgun glycomics of pig lung identifies natural endogenous receptors for influenza viruses.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- The roles of hemagglutinin Phe-95 in receptor binding and pathogenicity of influenza B virus.Virology · 2014Article
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- Modular glycosphere assays for high-throughput functional characterization of influenza viruses.BMC biotechnology · 2013Article
- Quantitative description of glycan-receptor binding of influenza A virus H7 hemagglutinin.PloS one · 2013Article
- Antigenic drift of the pandemic 2009 A(H1N1) influenza virus in A ferret model.PLoS pathogens · 2013Article
- Quantitative characterization of glycan-receptor binding of H9N2 influenza A virus hemagglutinin.PloS one · 2013Article
- Article
- Human monoclonal antibodies to pandemic 1957 H2N2 and pandemic 1968 H3N2 influenza viruses.Journal of virology · 2012Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
The H2N2 subtype of influenza A virus was responsible for the Asian pandemic of 1957-58. However, unlike other subtypes that have caused pandemics such as H1N1 and H3N2, which continue to circulate among humans, H2N2 stopped circulating in the human population in 1968. Strains of H2 subtype still continue to circulate in birds and occasionally pigs and could be reintroduced into the human population through antigenic drift or shift. Such an event is a potential global health concern because of the waning population immunity to H2 hemagglutinin (HA). The first step in such a cross-species transmission and human adaptation of influenza A virus is the ability for its surface glycoprotein HA to bind to glycan receptors expressed in the human upper respiratory epithelia. Recent structural and biochemical studies have focused on understanding the glycan receptor binding specificity of the 1957-58 pandemic H2N2 HA. However, there has been considerable HA sequence divergence in the recent avian-adapted H2 strains from the pandemic H2N2 strain. Using a combination of structural modeling, quantitative glycan binding and human respiratory tissue binding methods, we systematically identify mutations in the HA from a recent avian-adapted H2N2 strain (A/Chicken/PA/2004) that make its quantitative glycan receptor binding affinity (defined using an apparent binding constant) comparable to that of a prototypic pandemic H2N2 (A/Albany/6/58) HA.
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