ArticlePloS one2010
Correlation of global and gene-specific DNA methylation in maternal-infant pairs.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
42 citing papers in PubMed, 71 citations in OpenAlex.
- Trial
- No effect of weight loss on LINE-1 methylation levels in peripheral blood leukocytes from postmenopausal overweight women.Obesity (Silver Spring, Md.) · 2014Trial
- Mother adversity and co-residence time impact mother-child similarity in genome-wide and gene-specific methylation profiles.Clinical epigenetics · 2024Article
- The role of maternal DNA methylation in pregnancies complicated by gestational diabetes.Frontiers in clinical diabetes and healthcare · 2022Review
- Article
- Epigenetics in Families: Covariance between Mother and Child Methylation Patterns.Brain sciences · 2021Article
- Epigenome wide comparison of DNA methylation profile between paired umbilical cord blood and neonatal blood on Guthrie cards.Epigenetics · 2020Article
- Machine-learned analysis of global and glial/opioid intersection-related DNA methylation in patients with persistent pain after breast cancer surgery.Clinical epigenetics · 2019Article
- Lead in Air in Bangladesh: Exposure in a Rural Community with Elevated Blood Lead Concentrations among Young Children.International journal of environmental research and public health · 2018Article
- Transgenerational and intergenerational epigenetic inheritance in allergic diseases.The Journal of allergy and clinical immunology · 2018Review
- Methylation Levels of LINE-1 As a Useful Marker for Venous Invasion in Both FFPE and Frozen Tumor Tissues of Gastric Cancer.Molecules and cells · 2017Article
- Combined Effects of in Utero and Adolescent Tobacco Smoke Exposure on Lung Function in C57Bl/6J Mice.Environmental health perspectives · 2017Article
- DUSP1 promoter methylation in peripheral blood leukocyte is associated with triple-negative breast cancer risk.Scientific reports · 2017Article
- Neighborhood and Family Environment of Expectant Mothers May Influence Prenatal Programming of Adult Cancer Risk: Discussion and an Illustrative DNA Methylation Example.Biodemography and social biology · 2016Article
- Disagreement between two common biomarkers of global DNA methylation.Clinical epigenetics · 2016Article
- Global Methylation and Hydroxymethylation in DNA from Blood and Saliva in Healthy Volunteers.BioMed research international · 2015Article
- Differential Epigenetic Effects of Atmospheric Cold Plasma on MCF-7 and MDA-MB-231 Breast Cancer Cells.PloS one · 2015Article
- Sexual dimorphism in epigenomic responses of stem cells to extreme fetal growth.Nature communications · 2014Article
- Metabolic thrift and the genetic basis of human obesity.Annals of surgery · 2014Review
- Differences in DNA methylation by extent of breast cancer family history in unaffected women.Epigenetics · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
The inheritance of DNA methylation patterns is a popular theory to explain the influence of parental genetic and environmental factors on the phenotype of their offspring but few studies have examined this relationship in humans. Using 120 paired maternal-umbilical cord blood samples randomly selected from a prospective birth cohort in Bangladesh, we quantified DNA methylation by pyrosequencing seven CpG positions in the promoter region of p16, four CpG positions in the promoter region of p53, LINE-1 and Alu. Positive correlations were observed between maternal and umbilical cord blood at p16, LINE-1, and Alu but not p53. Multiple linear regression models observed a significant association between maternal and umbilical cord blood at LINE-1 and Alu (LINE-1: β = 0.63, p<0.0001; Alu: β = 0.28, p = 0.009). After adjusting for multiple comparisons, maternal methylation of p16 at position 4 significantly predicted methylation at the same position in umbilical cord blood (β = 0.43, p = <0.0001). These models explained 48%, 5% and 16% of the observed variability in umbilical cord %5mC for LINE-1, Alu and p16 at position 4, respectively. These results suggest that DNA methylation in maternal blood was correlated with her offspring at LINE-1, Alu, and p16 but not p53. Additional studies are needed to confirm whether these observed associations were due to the inheritance of epigenetic events or the shared environment between mother and fetus. Future studies should also use a multi-generational family-based design that would quantify both maternal and paternal contributions to DNA methylation in offspring across more than one generation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.