ArticleFrontiers in systems neuroscience2010
Studying network mechanisms using intracranial stimulation in epileptic patients.
Article in Frontiers in systems neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02844374 (Epileptogenic Zone's Cartography by Quantification of EEG's Signal and Intracerebral Stimulation.), which is not on this map. Cited by 36 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Epileptogenic Zone's Cartography by Quantification of EEG's Signal and Intracerebral Stimulation.
Who cites it
36 citing papers in PubMed.
- Resting-State vs. Task-Based Functional Magnetic Resonance Imaging in Neurosurgical Planning: A Narrative Review of Clinical Applications.Biomedicines · 2026Review
- Mapping the Epileptogenic Brain Using Low-Frequency Stimulation: Two Decades of Advances and Uncertainties.Journal of clinical medicine · 2025Review
- The prognostic value of cortical stimulation induced seizures using stereo EEG in presurgical evaluation of focal epilepsies.Scientific reports · 2025Article
- Intermodal Consistency of Whole-Brain Connectivity and Signal Propagation Delays.Human brain mapping · 2025Article
- Intracranial EEG-Based Directed Functional Connectivity in Alpha to Gamma Frequency Range Reflects Local Circuits of the Human Mesiotemporal Network.Brain topography · 2024Article
- Prognostic value of scalp EEG ictal patterns in epilepsy surgery of hippocampal sclerosis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Article
- Evoked responses to single pulse electrical stimulation reveal impaired striatal excitability in a rat model of Parkinson's disease.Neurobiology of disease · 2023Article
- Physiological and pathological neuronal connectivity in the living human brain based on intracranial EEG signals: the current state of research.Frontiers in network physiology · 2023Review
- Variability of Single Pulse Electrical Stimulation Responses Recorded with Intracranial Electroencephalography in Epileptic Patients.Brain topography · 2023Article
- Advances in human intracranial electroencephalography research, guidelines and good practices.NeuroImage · 2022Review
- Imaging the effective networks associated with cortical function through intracranial high-frequency stimulation.Human brain mapping · 2022Article
- The Insula: A Stimulating Island of the Brain.Brain sciences · 2021Review
- Functional Topography of Auditory Areas Derived From the Combination of Electrophysiological Recordings and Cortical Electrical Stimulation.Frontiers in human neuroscience · 2021Article
- Novel microwire-based biosensor probe for simultaneous real-time measurement of glutamate and GABA dynamics in vitro and in vivo.Scientific reports · 2020Article
- A taxonomy of seizure dynamotypes.eLife · 2020Article
- Pathological responses to single-pulse electrical stimuli in epilepsy: The role of feedforward inhibition.The European journal of neuroscience · 2020Article
- Somatosensory phenomena elicited by electrical stimulation of hippocampus: Insight into the ictal network.Epilepsy & behavior reports · 2020Article
- Quantifying epileptogenesis in rats with spontaneous and responsive brain state dynamics.Brain communications · 2020Article
- Electrical Stimulation Mapping of Brain Function: A Comparison of Subdural Electrodes and Stereo-EEG.Frontiers in human neuroscience · 2020Article
- Cortical Responses to Input From Distant Areas are Modulated by Local Spontaneous Alpha/Beta Oscillations.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Patients suffering from focal drug-resistant epilepsy who are explored using intracranial electrodes allow to obtain data of exceptional value for studying brain dynamics in correlation with pathophysiological and cognitive processes. Direct electrical stimulation (DES) of cortical regions and axonal tracts in those patients elicits a number of very specific perceptual or behavioral responses, but also abnormal responses due to specific configurations of epileptic networks. Here, we review how anatomo-functional brain connectivity and epilepsy network mechanisms can be assessed from DES responses measured in patients. After a brief summary of mechanisms of action of brain electrical stimulation, we recall the conceptual framework for interpreting DES results in the context of brain connectivity and review how DES can be used for the characterization of functional networks, the identification of the seizure onset zone, the study of brain plasticity mechanisms, and the anticipation of epileptic seizures. This pool of exceptional data may be underexploited by fundamental research on brain connectivity and leaves much to be learned.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.