ArticlePloS one2010
The presence of IL-17A and T helper 17 cells in experimental mouse brain tumors and human glioma.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
36 citing papers in PubMed, 54 citations in OpenAlex.
- Immune-Modulating Effects of Low-Carbohydrate Ketogenic Foods in Healthy Canines.Current developments in nutrition · 2024Article
- Gut epithelial Interleukin-17 receptor A signaling can modulate distant tumors growth through microbial regulation.Cancer cell · 2024Article
- Inhibitor of CD147 Suppresses T Cell Activation and Recruitment in CVB3-Induced Acute Viral Myocarditis.Viruses · 2023Article
- Long-term PMAging · 2020Article
- PD-L1/PD-1 Axis in Glioblastoma Multiforme.International journal of molecular sciences · 2019Review
- IL22 furthers malignant transformation of rat mesenchymal stem cells, possibly in association with IL22RA1/STAT3 signaling.Oncology reports · 2019Article
- Disruption of Intestinal Homeostasis and Intestinal Microbiota During Experimental Autoimmune Uveitis.Investigative ophthalmology & visual science · 2019Article
- Mesenchymal Stem Cells Derived and Cultured from Glioblastoma Multiforme Increase Tregs, Downregulate Th17, and Induce the Tolerogenic Phenotype of Monocyte-Derived Cells.Stem cells international · 2019Article
- IL-17A promotes cell migration and invasion of glioblastoma cells via activation of PI3K/AKT signalling pathway.Journal of cellular and molecular medicine · 2019Article
- Cytokine Networks and Survivin Peptide-Specific Cellular Immune Responses Predict Improved Survival in Patients With Glioblastoma Multiforme.EBioMedicine · 2018Article
- Short chain fatty acids ameliorate immune-mediated uveitis partially by altering migration of lymphocytes from the intestine.Scientific reports · 2017Article
- Type 1 Immune Mechanisms Driven by the Response to Infection with Attenuated Rabies Virus Result in Changes in the Immune Bias of the Tumor Microenvironment and Necrosis of Mouse GL261 Brain Tumors.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Targeting the Tumor Microenvironment: The Protumor Effects of IL-17 Related to Cancer Type.International journal of molecular sciences · 2016Review
- Preferential expression of functional IL-17R in glioma stem cells: potential role in self-renewal.Oncotarget · 2016Article
- Th1-, Th2-, and Th17-associated cytokine expression in hypopharyngeal carcinoma and clinical significance.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2016Article
- Article
- Vaccine therapies for patients with glioblastoma.Journal of neuro-oncology · 2014Review
- TJournal of cancer stem cell research · 2014Article
- Clinical significance of FOXP3 expression in human gliomas.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2014Article
- Role of IL-17 in Glioma Progression.Journal of spine & neurosurgery · 2013Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundRecently, CD4(+)IL-17A(+) T helper 17 (Th17) cells were identified and reported in several diseased states, including autoimmunity, infection and various peripheral nervous system tumors. However, the presence of Th17 in glia-derived tumors of the central nervous system has not been studied. METHODOLOGY/PRINCIPAL
findingsIn this report, we demonstrate that mRNA expression for the Th17 cell cytokine IL-17A, as well as Th17 cells, are present in human glioma. The mRNA expression for IL-17A in glioma was recapitulated in an immunocompetent mouse model of malignant glioma. Furthermore, the presence of Th17 cells was confirmed in both human and mouse glioma. Interestingly, some Th17 cells present in mouse glioma co-expressed the Th1 and Th2 lineage markers, IFN-γ and IL-4, respectively, but predominantly co-expressed the Treg lineage marker FoxP3.
conclusionsThese data confirm the presence of Th17 cells in glia-derived CNS tumors and provide the rationale for further investigation into the role of Th17 cells in malignant glioma.
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