ArticleProstate cancer and prostatic diseases2011
Prostate cancer gene expression signature of patients with high body mass index.
Article in Prostate cancer and prostatic diseases, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- The risks, degree of malignancy and clinical progression of prostate cancer associated with the MDM2 T309G polymorphism: a meta-analysis.Asian journal of andrology · 2012Pooled it
- Prostate cancer risk and aggressiveness associated with the CYP1B1 4326C/G (Leu432Val) polymorphism: a meta-analysis of 2788 cases and 2968 controls.Asian journal of andrology · 2012Pooled it
- Presurgical weight loss affects tumour traits and circulating biomarkers in men with prostate cancer.British journal of cancer · 2017Trial
- MicroRNA-6833-3p drives prostate cancer progression and stemness by targeting the NUMB-mediated NOTCH signaling pathway.Cell cycle (Georgetown, Tex.) · 2026Article
- Age and Tumor Differentiation-Associated Gene Expression Based Analysis of Non-Familial Prostate Cancers.Frontiers in oncology · 2020Article
- Multiplex profiling identifies clinically relevant signalling proteins in an isogenic prostate cancer model of radioresistance.Scientific reports · 2019Article
- Curcumin-Gene Expression Response in Hormone Dependent and Independent Metastatic Prostate Cancer Cells.International journal of molecular sciences · 2019Article
- Gene expression feature selection for prostate cancer diagnosis using a two-phase heuristic-deterministic search strategy.IET systems biology · 2018Article
- A Comparison of High Dimensional Variable Selection Methods with Missing Covariates in a Prostate Cancer Study.Communications in statistics. Case studies, data analysis and applications · 2018Article
- Article
- Novel Nine-Exon AR Transcripts (Exon 1/Exon 1b/Exons 2-8) in Normal and Cancerous Breast and Prostate Cells.International journal of molecular sciences · 2016Article
- Investigation of the molecular mechanisms underlying metastasis in prostate cancer by gene expression profiling.Experimental and therapeutic medicine · 2016Article
- 17β-estradiol induces stearoyl-CoA desaturase-1 expression in estrogen receptor-positive breast cancer cells.BMC cancer · 2015Article
- Using the canary genome to decipher the evolution of hormone-sensitive gene regulation in seasonal singing birds.Genome biology · 2015Article
- Reconstitution of the ERG Gene Expression Network Reveals New Biomarkers and Therapeutic Targets in ERG Positive Prostate Tumors.Journal of Cancer · 2015Article
- Regulatory mechanisms of testosterone-stimulated song in the sensorimotor nucleus HVC of female songbirds.BMC neuroscience · 2014Article
- NUMB inhibition of NOTCH signalling as a therapeutic target in prostate cancer.Nature reviews. Urology · 2014Review
- Beyond aspirin-cancer prevention with statins, metformin and bisphosphonates.Nature reviews. Clinical oncology · 2013Review
- Hypoxia, notch signalling, and prostate cancer.Nature reviews. Urology · 2013Review
- Obesity and prostate cancer: weighing the evidence.European urology · 2013Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
The goal of this study was to evaluate prostate cancer gene expression signatures associated with elevated body mass index (BMI). Global gene expression profiles of prostate tumor cells and matching normal epithelial cells were compared between patients with features of normal and high BMI at the time of radical prostatectomy. Knowledge-based analyses revealed an association of high BMI with altered levels of lipid metabolism and cholesterol homeostasis genes, such as stearoyl-CoA desaturase 1 (SCD1) and insulin-induced gene 1 (INSIG1), respectively, in prostate tumor cells. These genes were connected to known pathways of tumorigenesis revealed by the v-maf (musculoaponeurotic fibrosarcoma) oncogene homolog (MAF), notch receptor ligand, jagged 1 (JAG1) and the alanyl aminopeptidase (ANPEP/CD13) genes. This study highlighted that SCD1, a known target of statins, may have a mechanistic role in the recently noted beneficial effects of statin treatment in reducing biochemical recurrence of prostate cancer. An additional finding of our study is that some of the obesity-related genes were upregulated in tumor-matched normal cells within the high BMI group, when compared with normal cells within the normal BMI cohort.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.