ReviewNature reviews. Immunology2010
Farm living: effects on childhood asthma and allergy.
Review in Nature reviews. Immunology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT02148796 (Randomized, Placebo-controlled, Multicenter Study to Assess the Efficacy, Safety and Tolerability of ORal Bacterial EXtract for the Prevention of Wheezing Lower Respiratory Tract Illness), which is not on this map. Cited by 266 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Randomized, Placebo-controlled, Multicenter Study to Assess the Efficacy, Safety and Tolerability of ORal Bacterial EXtract for the Prevention of Wheezing Lower Respiratory Tract Illness (ORBEX)
Who cites it
266 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effects of isolated, confined and extreme environments on parameters of the immune system - a systematic review.Frontiers in immunology · 2025Pooled it
- Article
- Atopic outcomes at 5 years in the CORAL cohort born during the 2020 COVID-19 lockdown.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2026Observational
- Prevalence and risk factors of asthma, allergic rhinitis, and atopic dermatitis among schoolchildren in Sri Lanka.The journal of allergy and clinical immunology. Global · 2026Article
- Helicobacter pylori infection carrying the CagA gene may be associated with the diagnosis and disease progression of tuberculosis.BMC infectious diseases · 2026Article
- The Gut-Lung Axis in Allergic Asthma: A Narrative Review of Microbial Dysbiosis, Immune Regulation, and Nutritional Modulation.Nutrients · 2026Review
- Environmental microbiota transfer from forest soil into urban homes: a proof-of-principle study.Microbiome · 2026Article
- Comparable efficacy and mechanisms of sterile soil ingestion versus low hygiene exposure in DSS-induced colitis.Applied and environmental microbiology · 2026Article
- Context-dependent roles of the gut microbiome in food allergy tolerance versus sensitization.Gut microbes · 2025Review
- The role of the early-life gut microbiome in childhood asthma.Gut microbes · 2025Review
- Why Every Asthma Patient Tells a Different Story.Journal of clinical medicine · 2025Article
- Oral microbiota and respiratory diseases: advances and perspectives.Clinical microbiology reviews · 2025Review
- Macronutrients, Micronutrients, and Malnutrition: Effects of Nutrition on Immune Function in Infants and Young Children.Nutrients · 2025Review
- Effect of Heat Pasteurization and Sterilization on Milk Safety, Composition, Sensory Properties, and Nutritional Quality.Foods (Basel, Switzerland) · 2025Review
- Regulatory T-Cells During Pregnancy Relate to Women's Own Childhood History of Microbial Exposure.American journal of human biology : the official journal of the Human Biology Council · 2025Article
- The role of wheezing subtypes in the development of early childhood asthma.Respiratory research · 2025Article
- Clinical and Pathophysiological Tangles Between Allergy and Autoimmunity: Deconstructing an Old Dichotomic Paradigm.Clinical reviews in allergy & immunology · 2025Review
- Microbial indoor air pollution in Delhi Metropolitan City is attributable to severe respiratory and general health effects among residents.Frontiers in public health · 2025Article
- A Study to Evaluate the Role of Probiotics in Allergic Rhinitis.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2024Article
- IgE versus IgG and IgA: Differential roles of allergen-specific antibodies in sensitization, tolerization, and treatment of allergies.Immunological reviews · 2024Review
206 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Numerous epidemiological studies have shown that children who grow up on traditional farms are protected from asthma, hay fever and allergic sensitization. Early-life contact with livestock and their fodder, and consumption of unprocessed cow's milk have been identified as the most effective protective exposures. Studies of the immunobiology of farm living point to activation and modulation of innate and adaptive immune responses by intense microbial exposures and possibly xenogeneic signals delivered before or soon after birth.
Indexed as
Identifiers
21060319What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.