ArticleNeurology2010
White matter hyperintensity volume is increased in small vessel stroke subtypes.
Article in Neurology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers, 6 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
91 citing papers in PubMed, 6 syntheses or guidelines pooled it, 147 citations in OpenAlex.
- Characterization of White Matter Hyperintensities in Large-Scale MRI-Studies.Frontiers in neurology · 2019Pooled it
- Candidate-gene analysis of white matter hyperintensities on neuroimaging.Journal of neurology, neurosurgery, and psychiatry · 2016Pooled it
- Genome-wide meta-analysis of cerebral white matter hyperintensities in patients with stroke.Neurology · 2016Pooled it
- Common variation in COL4A1/COL4A2 is associated with sporadic cerebral small vessel disease.Neurology · 2015Pooled it
- Meta-analysis of genome-wide association studies identifies 1q22 as a susceptibility locus for intracerebral hemorrhage.American journal of human genetics · 2014Pooled it
- Pooled it
- The association between lacunes and white matter hyperintensity features on MRI: The SMART-MR study.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2019Trial
- Estimating intracranial volume using intracranial area in healthy children and those with childhood status epilepticus.Brain and behavior · 2014Trial
- High estimated pulse-wave velocity is associated with lower brain white matter microstructural integrity twelve years later.Neurobiology of aging · 2025Article
- Distinct spatiotemporal patterns of white matter hyperintensity progression.Nature communications · 2025Article
- Sex differences in age-associated neurological diseases-A roadmap for reliable and high-yield research.Science advances · 2025Review
- Quantifying Cognitive Function in Diabetes: Relationships Between AD8 Scores, HbA1c Levels, and Other Diabetic Comorbidities.Biomedicines · 2025Article
- Equol Nonproducing Status as an Independent Risk Factor for Acute Cardioembolic Stroke and Poor Functional Outcome.Nutrients · 2024Article
- White Matter Hyperintensity in Patients with Sudden Sensorineural Hearing Loss.Diagnostics (Basel, Switzerland) · 2024Article
- Impact of white matter hyperintensity volumes estimated by automated methods using deep learning on stroke outcomes in small vessel occlusion stroke.Frontiers in aging neuroscience · 2024Article
- Trimethylamine N-Oxide and White Matter Hyperintensity Volume Among Patients With Acute Ischemic Stroke.JAMA network open · 2023Observational
- Analysis of Risk Factors for White Matter Hyperintensity in Older Adults without Stroke.Brain sciences · 2023Article
- Systematic Mendelian randomization using the human plasma proteome to discover potential therapeutic targets for stroke.Nature communications · 2022Article
- Association between white matter hyperintensity volume and social functioning limitations among stroke survivors.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2022Article
- Effects of cerebral small vessel disease on the outcomes in cryptogenic stroke with active cancer.Scientific reports · 2021Article
31 more citing papers are in PubMed but not listed here.
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Authors and funding
15 authors at 5 institutions in 2 countries.
Funding
Abstract
objectiveWhite matter hyperintensity (WMH) may be a marker of an underlying cerebral microangiopathy. Therefore, we hypothesized that WMH would be most severe in patients with lacunar stroke and intracerebral hemorrhage (ICH), 2 types of stroke in which cerebral small vessel (SV) changes are pathophysiologically relevant.
methodsWe determined WMH volume (WMHV) in cohorts of prospectively ascertained patients with acute ischemic stroke (AIS) (Massachusetts General Hospital [MGH], n = 628, and the Ischemic Stroke Genetics Study [ISGS], n = 263) and ICH (MGH, n = 122).
resultsMedian WMHV was 7.5 cm³ (interquartile range 3.4-14.7 cm³) in the MGH AIS cohort (mean age 65 ± 15 years). MGH patients with larger WMHV were more likely to have lacunar stroke compared with cardioembolic (odds ratio [OR] = 1.87 per SD normally transformed WMHV), large artery (OR = 2.25), undetermined (OR = 1.87), or other (OR = 1.85) stroke subtypes (p < 0.03). These associations were replicated in the ISGS cohort (p = 0.03). In a separate analysis, greater WMHV was seen in ICH compared with lacunar stroke (OR = 1.2, p < 0.02) and in ICH compared with all ischemic stroke subtypes combined (OR = 1.34, p < 0.007).
conclusionsGreater WMH burden was associated with SV stroke compared with other ischemic stroke subtypes and, even more strongly, with ICH. These data, from 2 independent samples, support the model that increasing WMHV is a marker of more severe cerebral SV disease and provide further evidence for links between the biology of WMH and SV stroke.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.