ArticleProceedings of the National Academy of Sciences of the United States of America2010
Three-amino-acid-loop-extension homeodomain factor Meis3 regulates cell survival via PDK1.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 34 citations in OpenAlex.
- Article
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- Natural variation in the GhTTL promoter modulates cotton fiber elongation through the GhTALE-GhTTL-GhBIN2 module.Plant communications · 2025Article
- Disruption of GPSM1/CSF1 signaling reprograms tumor-associated macrophages to overcome anti-PD-1 resistance in colorectal cancer.Journal for immunotherapy of cancer · 2025Article
- Integrative multi-omics identifies MEIS3 as a diagnostic biomarker and immune modulator in hypertrophic cardiomyopathy.Frontiers in immunology · 2025Article
- HDAC Inhibition with Valproate Improves Direct Cytotoxicity of Monocytes against Mesothelioma Tumor Cells.Cancers · 2022Article
- Effect of myeloid ecotropic viral integration site (MEIS) family genes on tumor microenvironment remodeling and its potential therapeutic effect.Translational andrology and urology · 2021Article
- Inhibition ofBioMed research international · 2020Article
- Oncogenic and tumor suppressor function of MEIS and associated factors.Turkish journal of biology = Turk biyoloji dergisi · 2020Article
- Tumor-Suppressive Role of microRNA-202-3p in Hepatocellular Carcinoma Through the KDM3A/HOXA1/MEIS3 Pathway.Frontiers in cell and developmental biology · 2020Article
- RepeatFiller newly identifies megabases of aligning repetitive sequences and improves annotations of conserved non-exonic elements.GigaScience · 2019Article
- Germ cell-intrinsic requirement for the homeodomain transcription factor PKnox1/Prep1 in adult spermatogenesis.PloS one · 2018Article
- Complement receptor 2 is up regulated in the spinal cord following nerve root injury and modulates the spinal cord response.Journal of neuroinflammation · 2015Article
- The PDK1 master kinase is over-expressed in acute myeloid leukemia and promotes PKC-mediated survival of leukemic blasts.Haematologica · 2014Article
- The diabetes gene Hhex maintains δ-cell differentiation and islet function.Genes & development · 2014Article
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- Cisplatin resistance: a cellular self-defense mechanism resulting from multiple epigenetic and genetic changes.Pharmacological reviews · 2012Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Three-amino-acid-loop-extension (TALE) homeodomain proteins including Meis and Pbx families are generally recognized for their roles in growth and differentiation during vertebrate embryogenesis and tumorigenesis. Whereas genetic studies indicate that Pbx1 regulates the development and function of insulin-producing pancreatic β-cells, the role of Meis family members in β-cells is still unknown. Here we show that Meis3 is abundantly expressed in pancreatic islets and β-cells and that it regulates β-cell survival. We further identify the 3-phosphoinositide-dependent protein kinase 1 (PDK1), a well-known kinase involved in the PI3K-Akt signaling pathway, as a direct Meis3 target, which mediates its role in β-cell survival. This regulatory module appears to function broadly as we also identify Meis3 regulation of cell survival and PDK1 expression in ovarian carcinoma cells, suggesting a unique function for Meis3 beyond the traditional roles for TALE homeodomain factors during embryogenesis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.