ArticleJournal of immunology (Baltimore, Md. : 1950)2010
Semen protects CD4+ target cells from HIV infection but promotes the preferential transmission of R5 tropic HIV.
Article in Journal of immunology (Baltimore, Md. : 1950), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 35 citations in OpenAlex.
- Mucosal Dynamics Contributing to Innate Immune Responses to HIV in the Human Female Genital Tract.Viruses · 2026Review
- Utilization of Aminoguanidine Prevents Cytotoxic Effects of Semen.International journal of molecular sciences · 2022Article
- Semen: A modulator of female genital tract inflammation and a vector for HIV-1 transmission.American journal of reproductive immunology (New York, N.Y. : 1989) · 2021Review
- HIV-1 subverts the complement system in semen to enhance viral transmission.Mucosal immunology · 2021Article
- HIV Pathogenesis in the Human Female Reproductive Tract.Current HIV/AIDS reports · 2021Review
- Role of Complement Receptors (CRs) on DCs in Anti-HIV-1 Immunity.Frontiers in immunology · 2020Review
- Modulation of the CCR5 Receptor/Ligand Axis by Seminal Plasma and the Utility ofJournal of virology · 2019Article
- Vehicles of intercellular communication: exosomes and HIV-1.The Journal of general virology · 2019Review
- Immune biomarkers and anti-HIV activity in the reproductive tract of sexually active and sexually inactive adolescent girls.American journal of reproductive immunology (New York, N.Y. : 1989) · 2018Article
- Comparison of the effect of semen from HIV-infected and uninfected men on CD4+ T-cell infection.AIDS (London, England) · 2016Article
- Characterization of the Influence of Semen-Derived Enhancer of Virus Infection on the Interaction of HIV-1 with Female Reproductive Tract Tissues.Journal of virology · 2015Article
- The regulation of inflammatory pathways and infectious disease of the cervix by seminal fluid.Pathology research international · 2014Review
- Article
- Human seminal plasma fosters CD4(+) regulatory T-cell phenotype and transforming growth factor-β1 expression.American journal of reproductive immunology (New York, N.Y. : 1989) · 2012Article
- The Surprising Role of Amyloid Fibrils in HIV Infection.Biology · 2012Article
- Seminal plasma accelerates semen-derived enhancer of viral infection (SEVI) fibril formation by the prostatic acid phosphatase (PAP248-286) peptide.The Journal of biological chemistry · 2012Article
- CCR5 expression is elevated on endocervical CD4+ T cells in healthy postmenopausal women.Journal of acquired immune deficiency syndromes (1999) · 2012Article
- Naturally occurring fragments from two distinct regions of the prostatic acid phosphatase form amyloidogenic enhancers of HIV infection.Journal of virology · 2012Article
- Peptides released by physiological cleavage of semen coagulum proteins form amyloids that enhance HIV infection.Cell host & microbe · 2011Article
- Tissue-specific HIV-1 infection: why it matters.Future virology · 2011Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Sexual intercourse is the major means of HIV transmission, yet the impact of semen on HIV infection of CD4(+) T cells remains unclear. To resolve this conundrum, we measured CD4(+) target cell infection with X4 tropic HIV IIIB and HC4 and R5 tropic HIV BaL and SF162 after incubation with centrifuged seminal plasma (SP) from HIV-negative donors and assessed the impact of SP on critical determinants of target cell susceptibility to HIV infection. We found that SP potently protects CD4(+) T cells from infection with X4 and R5 tropic HIV in a dose- and time-dependent manner. SP caused a diminution in CD4(+) T cell surface expression of the HIVR CD4 and enhanced surface expression of the HIV coreceptor CCR5. Consequently, SP protected CD4(+) T cells from infection with R5 tropic HIV less potently than it protected CD4(+) T cells from infection with X4 tropic HIV. SP also reduced CD4(+) T cell activation and proliferation, and the magnitude of SP-mediated suppression of target cell CD4 expression, activation, and proliferation correlated closely with the magnitude of the protection of CD4(+) T cells from infection with HIV. Taken together, these data show that semen protects CD4(+) T cells from HIV infection by restricting critical determinants of CD4(+) target cell susceptibility to HIV infection. Further, semen contributes to the selective transmission of R5 tropic HIV to CD4(+) target cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.