ArticleEuropean journal of endocrinology2011
Serum proteome changes in acromegalic patients following transsphenoidal surgery: novel biomarkers of disease activity.
Article in European journal of endocrinology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
- Novel serum protein biomarkers indicative of growth hormone doping in healthy human subjects.Proteomics · 2011Trial
- Multiomics Approach to Acromegaly: Unveiling Translational Insights for Precision Medicine.Endocrinology and metabolism (Seoul, Korea) · 2023Review
- The Proteomic Signature of Recombinant Growth Hormone in Recreational Athletes.Journal of the Endocrine Society · 2021Article
- Article
- Metabolic profiling of acromegaly using a GC-MS-based nontargeted metabolomic approach.Endocrine · 2020Article
- Growth Hormone and Neuronal Hemoglobin in the Brain-Roles in Neuroprotection and Neurodegenerative Diseases.Frontiers in endocrinology · 2020Review
- Proteomic Analysis of Human Esophageal Cancer Using Tandem Mass Tag Quantifications.BioMed research international · 2020Article
- Article
- Growth Hormone Research Society perspective on biomarkers of GH action in children and adults.Endocrine connections · 2018Review
- The impact of growth hormone on proteomic profiles: a review of mouse and adult human studies.Clinical proteomics · 2017Review
- Heterogeneity analysis of the proteomes in clinically nonfunctional pituitary adenomas.BMC medical genomics · 2014Article
- Decreased insulin sensitivity and increased oxidative damage in wasting adipose tissue depots of wild-type mice.Age (Dordrecht, Netherlands) · 2012Article
- Heterogeneity among white adipose tissue depots in male C57BL/6J mice.Obesity (Silver Spring, Md.) · 2012Article
- Plasma proteomic profiles of bovine growth hormone transgenic mice as they age.Transgenic research · 2011Article
- Differential effects of growth hormone versus insulin-like growth factor-I on the mouse plasma proteome.Endocrinology · 2011Article
- Identification of new biomarkers of low-dose GH replacement therapy in GH-deficient patients.The Journal of clinical endocrinology and metabolism · 2011Article
- Proteomic changes in the heart of diet-induced pre-diabetic mice.Journal of proteomics · 2011Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
contextTranssphenoidal adenomectomy is the primary treatment for acromegaly. However, assessment of the therapeutical outcome remains problematic since the existing biomarkers of disease activity frequently show discordant results.
objectiveTo discover novel serum biomarkers of disease activity in acromegalic patients before and after surgery.
designSerum samples of eight newly diagnosed acromegaly patients before and after transsphenoidal surgery were analyzed for proteomic changes by two-dimensional gel electrophoresis. Protein spots displaying statistically significant changes, pre- versus post-surgery, were identified by mass spectrometry (MS), tandem MS (MS/MS), and western blot analysis.
resultsSix protein spots displaying decreased intensities after surgery were identified as transthyretin (two isoforms), haptoglobin α2, β-hemoglobin, and apolipoprotein A-1 (two isoforms). One protein spot, identified as complement C4B precursor, was increased after the surgery.
conclusionsSeven serum protein spots were differentially expressed following surgery in acromegalic patients. The identified proteins represent potential novel biomarkers to assess the effectiveness of surgical treatment in acromegalic individuals. Future studies will validate the use of the identified proteins as biomarkers of disease activity after medical treatment of acromegaly.
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