ArticleCirculation. Cardiovascular imaging2011
Long-term improvement in postinfarct left ventricular global and regional contractile function is mediated by embryonic stem cell-derived cardiomyocytes.
Article in Circulation. Cardiovascular imaging, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 51 citations in OpenAlex.
- Macrophages suppress cardiac reprogramming of fibroblasts in vivo via IFN-mediated intercellular self-stimulating circuit.Protein & cell · 2024Article
- Genome Editing and Cardiac Regeneration.Advances in experimental medicine and biology · 2023Article
- Single-photon emission computed tomography as a fundamental tool in evaluation of myocardial reparation and regeneration therapies.Postepy w kardiologii interwencyjnej = Advances in interventional cardiology · 2022Review
- Cardiac Cell Therapy with Pluripotent Stem Cell-Derived Cardiomyocytes: What Has Been Done and What Remains to Do?Current cardiology reports · 2022Review
- Strategies to improve the therapeutic effect of pluripotent stem cell-derived cardiomyocytes on myocardial infarction.Frontiers in bioengineering and biotechnology · 2022Review
- Perspective on human pluripotent stem cell-derived cardiomyocytes in heart disease modeling and repair.Stem cells translational medicine · 2020Article
- Function Follows Form - A Review of Cardiac Cell Therapy.Circulation journal : official journal of the Japanese Circulation Society · 2019Review
- The small molecule Chicago Sky Blue promotes heart repair following myocardial infarction in mice.JCI insight · 2019Article
- Irisin promotes cardiac progenitor cell-induced myocardial repair and functional improvement in infarcted heart.Journal of cellular physiology · 2019Article
- Therapeutic approaches for cardiac regeneration and repair.Nature reviews. Cardiology · 2018Review
- Cell Therapies in Cardiomyopathy: Current Status of Clinical Trials.Analytical cellular pathology (Amsterdam) · 2017Review
- Cardiac melanocytes influence atrial reactive oxygen species involved with electrical and structural remodeling in mice.Physiological reports · 2015Article
- Magnetic resonance imaging with superparamagnetic iron oxide fails to track the long-term fate of mesenchymal stem cells transplanted into heart.Scientific reports · 2015Article
- Strategies for cardiac regeneration and repair.Science translational medicine · 2014Review
- Article
- Three-dimensional regional strain analysis in porcine myocardial infarction: a 3T magnetic resonance tagging study.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2012Article
- Spin-labeling magnetic resonance imaging detects increased myocardial blood flow after endothelial cell transplantation in the infarcted heart.Circulation. Cardiovascular imaging · 2012Article
- Embryonic stem cell-based cardiopatches improve cardiac function in infarcted rats.Stem cells translational medicine · 2012Article
- Imaging Cell Therapy for Myocardial Regeneration.Current cardiovascular imaging reports · 2012Article
- Tracking stem cells for cardiovascular applications in vivo: focus on imaging techniques.Imaging in medicine · 2011Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
backgroundPluripotent stem cells represent one promising source for cellular cardiomyoplasty. In this study, we used cardiac magnetic resonance to examine the ability of highly enriched cardiomyocytes (CMs) derived from murine embryonic stem cells (ESC) to form grafts and improve contractile function of infarcted rat hearts. METHODS AND
resultsHighly enriched ESC-CMs were obtained by inducing cardiac differentiation of ESCs stably expressing a cardiac-restricted puromycin resistance gene. At the time of transplantation, enriched ESC-CMs expressed cardiac-specific markers and markers of developing CMs, but only 6% of them were proliferating. A growth factor-containing vehicle solution or ESC-CMs (5 to 10 million) suspended in the same solution was injected into athymic rat hearts 1 week after myocardial infarction. Initial infarct size was measured by cardiac magnetic resonance 1 day after myocardial infarction. Compared with vehicle treatment, treatment with ESC-CMs improved global systolic function 1 and 2 months after injection and significantly increased contractile function in initially infarcted areas and border zones. Immunohistochemistry confirmed successful engraftment and the persistence of α-actinin-positive ESC-CMs that also expressed α-smooth muscle actin. Connexin-43-positive sites were observed between grafted ESC-CMs but only rarely between grafted and host CMs. No teratomas were observed in any of the animals.
conclusionsHighly enriched and early-stage ESC-CMs were safe, formed stable grafts, and mediated a long-term recovery of global and regional myocardial contractile function after infarction.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.