ArticleOsteoarthritis and cartilage2011
Recommendations for standardization and phenotype definitions in genetic studies of osteoarthritis: the TREAT-OA consortium.
Article in Osteoarthritis and cartilage, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 8 of them syntheses that pooled it.
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41 citing papers in PubMed, 8 syntheses or guidelines pooled it, 88 citations in OpenAlex.
- Recreational Physical Activity and Risk of Incident Knee Osteoarthritis: An International Meta-Analysis of Individual Participant-Level Data.Arthritis & rheumatology (Hoboken, N.J.) · 2022Pooled it
- Meta-analysis of Icelandic and UK data sets identifies missense variants in SMO, IL11, COL11A1 and 13 more new loci associated with osteoarthritis.Nature genetics · 2018Pooled it
- Genome-wide association and functional studies identify a role for IGFBP3 in hip osteoarthritis.Annals of the rheumatic diseases · 2015Pooled it
- A meta-analysis of genome-wide association studies identifies novel variants associated with osteoarthritis of the hip.Annals of the rheumatic diseases · 2014Pooled it
- Severe osteoarthritis of the hand associates with common variants within the ALDH1A2 gene and with rare variants at 1p31.Nature genetics · 2014Pooled it
- Assessment of osteoarthritis candidate genes in a meta-analysis of nine genome-wide association studies.Arthritis & rheumatology (Hoboken, N.J.) · 2014Pooled it
- The DOT1L rs12982744 polymorphism is associated with osteoarthritis of the hip with genome-wide statistical significance in males.Annals of the rheumatic diseases · 2013Pooled it
- European Project on OSteoArthritis (EPOSA): methodological challenges in harmonization of existing data from five European population-based cohorts on aging.BMC musculoskeletal disorders · 2011Pooled it
- Correlation of inflammatory mediators with osteophyte formation in end-stage knee osteoarthritis.Scientific reports · 2026Article
- Deciphering the Relationship Between Circulating Metabolites and Osteoarthritis: A Comprehensive Genetic Correlation and Mendelian Randomization Studies.International journal of medical sciences · 2025Article
- Genetic insights into the risk of hip osteoarthritis on stroke: A single-variable and multivariable Mendelian randomization.PloS one · 2025Article
- Osteoarthritis, coronary artery disease, and myocardial infarction: A mendelian randomization study.Frontiers in cardiovascular medicine · 2022Article
- Article
- Vitamin K antagonist anticoagulant usage is associated with increased incidence and progression of osteoarthritis.Annals of the rheumatic diseases · 2021Article
- The Hertfordshire Cohort Study: an overview.F1000Research · 2019Review
- Harmonising measures of knee and hip osteoarthritis in population-based cohort studies: an international study.Osteoarthritis and cartilage · 2018Article
- FTO variant is not associated with osteoarthritis in the Chinese Han population: replication study for a genome-wide association study identified risk loci.Journal of orthopaedic surgery and research · 2018Article
- The associations between radiographic hand osteoarthritis definitions and hand pain: data from the osteoarthritis initiative.Rheumatology international · 2018Article
- Radiographic endophenotyping in hip osteoarthritis improves the precision of genetic association analysis.Annals of the rheumatic diseases · 2017Article
- Genome-Wide Association Study of Radiographic Knee Osteoarthritis in North American Caucasians.Arthritis & rheumatology (Hoboken, N.J.) · 2017Article
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50 authors at 20 institutions in 12 countries.
Funding
Abstract
objectiveTo address the need for standardization of osteoarthritis (OA) phenotypes by examining the effect of heterogeneity among symptomatic (SOA) and radiographic osteoarthritis (ROA) phenotypes.
methodsDescriptions of OA phenotypes of the 28 studies involved in the TREAT-OA consortium were collected. We investigated whether different OA definitions result in different association results by creating various hip OA definitions in one large population based cohort (the Rotterdam Study I (RSI)) and testing those for association with gender, age and body mass index using one-way ANOVA. For ROA, we standardized the hip-, knee- and hand ROA definitions and calculated prevalence's of ROA before and after standardization in nine cohort studies. This procedure could only be performed in cohort studies and standardization of SOA definitions was not feasible at this moment.
resultsIn this consortium, all studies with SOA phenotypes (knee, hip and hand) used a different definition and/or assessment of OA status. For knee-, hip- and hand ROA five, four and seven different definitions were used, respectively. Different hip ROA definitions do lead to different association results. For example, we showed in the RSI that hip OA defined as "at least definite joint space narrowing (JSN) and one definite osteophyte" was not associated with gender (P =0.22), but defined as "at least one definite osteophyte" was significantly associated with gender (P=3×10(-9)). Therefore, a standardization process was undertaken for ROA definitions. Before standardization a wide range of ROA prevalence's was observed in the nine cohorts studied. After standardization the range in prevalence of knee- and hip ROA was small.
conclusionPhenotype definitions influence the prevalence of OA and association with clinical variables. ROA phenotypes within the TREAT-OA consortium were standardized to reduce heterogeneity and improve power in future genetics studies.
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