ArticlePhysiology & behavior2011
Age-dependent alterations in nerve growth factor (NGF)-related proteins, sortilin, and learning and memory in rats.
Article in Physiology & behavior, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
45 citing papers in PubMed, 83 citations in OpenAlex.
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- Gene cloning of S100β and NGF and localization of their expression in the small intestine of broilers of various ages.Scientific reports · 2025Article
- It Is Time to Consider the Lost Battle of Microdamaged Piezo2 in the Context ofInternational journal of molecular sciences · 2025Review
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- The winter is coming: seasonal variations in BDNF levels among older adults in a high-latitude region - a preliminary study.Frontiers in psychiatry · 2025Article
- 1953-2023. Seventy Years of the Nerve Growth Factor: A Potential Novel Treatment in Neurological Diseases?Aging and disease · 2024Review
- Expression of NGF, proNGF, p75Clinics (Sao Paulo, Brazil) · 2024Article
- Article
- Polyphenols' Impact on Selected Biomarkers of Brain Aging in Healthy Middle-Aged and Elderly Subjects: A Review of Clinical Trials.Nutrients · 2023Review
- Age-induced nitrative stress decreases retrograde transport of proNGF via TrkA and increases proNGF retrograde transport and neurodegeneration via p75Frontiers in molecular neuroscience · 2023Article
- Evidence for preserved insulin responsiveness in the aging rat brain.GeroScience · 2022Article
- The Role of Neurotrophin Signaling in Age-Related Cognitive Decline and Cognitive Diseases.International journal of molecular sciences · 2022Review
- A Novel and Selective Dopamine Transporter Inhibitor,Biomolecules · 2022Article
- Expression of Selected Genes Involved in Neurogenesis in the Etiopathogenesis of Depressive Disorders.Journal of personalized medicine · 2021Article
- Age-related changes in hippocampal-dependent synaptic plasticity and memory mediated by p75 neurotrophin receptor.Aging cell · 2021Article
- Intervention of Brain-Derived Neurotrophic Factor and Other Neurotrophins in Adult Neurogenesis.Advances in experimental medicine and biology · 2021Review
- Effects of iTBS-rTMS on the Behavioral Phenotype of a Rat Model of Maternal Immune Activation.Frontiers in behavioral neuroscience · 2021Article
- Effects of (-)-epicatechin on neuroinflammation and hyperphosphorylation of tau in the hippocampus of aged mice.Food & function · 2020Article
- Modulation of the p75 neurotrophin receptor suppresses age-related basal forebrain cholinergic neuron degeneration.Scientific reports · 2019Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The objective of this study was to evaluate the effects of aging on the performance of specific memory-related tasks in rats as well as to determine the levels of several nerve growth factor (NGF)-related proteins in relevant brain regions. The results indicated age-related impairments in spatial learning in a water maze task as well as deficits in recognition memory in a Spontaneous Novel Object Recognition task. In the prefrontal cortex and hippocampus, aged rats (compared to young controls) had elevated levels of the proneurotrophin, proNGF (+1.8-1.9 fold), p75(NTR) receptors (+1.6-1.8 fold) and sortilin (+1.8-2.1 fold), and decreased levels of mature NGF (-36 to 44%), and phospho-TrkA receptors (-45 to 49%). The results of this study support the argument that NGF signaling is altered in the aging brain, and that such alterations may contribute to an age-related decline in cognitive function. These results may also help to identify specific components of the NGF-signaling pathway that could serve as targets for novel drug discovery and development for age-related disorders of cognition (e.g., Alzheimer's disease).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.