ArticleBMC gastroenterology2010
Lymphatic marker podoplanin/D2-40 in human advanced cirrhotic liver--re-evaluations of microlymphatic abnormalities.
Article in BMC gastroenterology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 38 citations in OpenAlex.
- Effect of Lymphatic Invasion on Survival and Recurrence After Liver Transplantation in Patients with Hepatocellular Carcinoma and Its Prognostic Significance.Diagnostics (Basel, Switzerland) · 2026Article
- Prognostic Significance of Hemoglobin, Albumin, Lymphocyte, and Platelet (HALP) Score in Liver Transplantation for Hepatocellular Carcinoma.Current oncology (Toronto, Ont.) · 2025Article
- Platelet activation relieves liver portal hypertensionWorld journal of gastroenterology · 2025Article
- Laparoscopic Distal Pancreatectomy for Lymph Node Metastasis around Splenic Artery from Hepatocellular Carcinoma in a Patient with Portal Annular Pancreas.Surgical case reports · 2025Article
- Prevalence and risk factors of lymphatic dysfunction in cirrhosis patients with refractory ascites: An often unconsidered mechanism.World journal of hepatology · 2023Article
- Review
- Podoplanin-positive dilated lymphatic vessels in duodenum associates with three-month mortality in patients with cirrhosis.Frontiers in physiology · 2023Article
- Three-dimensional mapping of hepatic lymphatic vessels and transcriptome profiling of lymphatic endothelial cells in healthy and diseased livers.Theranostics · 2023Article
- Paneth Cells Regulate Lymphangiogenesis under Control of Microbial Signals during Experimental Portal Hypertension.Biomedicines · 2022Article
- Targeting Lymphangiogenesis and Lymph Node Metastasis in Liver Cancer.The American journal of pathology · 2021Review
- Lymphatic dysfunction in advanced cirrhosis: Contextual perspective and clinical implications.World journal of hepatology · 2021Review
- Lymphatic Programing and Specialization in Hybrid Vessels.Frontiers in physiology · 2020Review
- Digestion of the Murine Liver for a Flow Cytometric Analysis of Lymphatic Endothelial Cells.Journal of visualized experiments : JoVE · 2019Article
- Chronic Liver Disease in Humans Causes Expansion and Differentiation of Liver Lymphatic Endothelial Cells.Frontiers in immunology · 2019Article
- Emerging Roles for Lymphatics in Chronic Liver Disease.Frontiers in physiology · 2019Review
- Antineutrophil Cytoplasmic Antibody-Associated Vasculitis in Korea: A Narrative Review.Yonsei medical journal · 2019Review
- Liver sinusoidal endothelial cells - gatekeepers of hepatic immunity.Nature reviews. Gastroenterology & hepatology · 2018Review
- Lymphatics in the liver.Current opinion in immunology · 2018Review
- The Hepatic Lymphatic Vascular System: Structure, Function, Markers, and Lymphangiogenesis.Cellular and molecular gastroenterology and hepatology · 2016Review
- The Role of Lymphatic Endothelial Cells in Liver Injury and Tumor Development.Frontiers in immunology · 2016Review
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFrom the morphological appearance, it was impossible to distinguish terminal portal venules from small lymphatic vessels in the portal tract even using histochemical microscopic techniques. Recently, D2-40 was found to be expressed at a high level in lymphatic endothelial cells (LECs). This study was undertaken to elucidate hepatic lymphatic vessels during progression of cirrhosis by examining the expression of D2-40 in LECs.
methodsSurgical wedge biopsy specimens were obtained from non-cirrhotic portions of human livers (normal control) and from cirrhotic livers (LC) (Child A-LC and Child C-LC). Immunohistochemical (IHC), Western blot, and immunoelectron microscopic studies were conducted using D2-40 as markers for lymphatic vessels, as well as CD34 for capillary blood vessels.
resultsImunostaining of D2-40 produced a strong reaction in lymphatic vessels only, especially in Child C-LC. It was possible to distinguish the portal venules from the small lymphatic vessels using D-40. Immunoelectron microscopy revealed strong D2-40 expression along the luminal and abluminal portions of the cell membrane of LECs in Child C-LC tissue.
conclusionIt is possible to distinguish portal venules from small lymphatic vessels using D2-40 as marker. D2-40- labeling in lymphatic capillary endothelial cells is related to the degree of fibrosis in cirrhotic liver.
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Registered trials
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