ArticleKnee surgery, sports traumatology, arthroscopy : official journal of the ESSKA2011
Scanty integration of osteochondral allografts cryopreserved at low temperatures with dimethyl sulfoxide.
Article in Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Histological scoring systems for tissue-engineered, ex vivo and degenerative meniscus.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2013Pooled it
- Two-stage bone and meniscus allograft and autologous chondrocytes implant for unicompartmental osteoarthritis: midterm results.Musculoskeletal surgery · 2022Article
- Arthroscopic Tenotomy of the Long Head of the Biceps Tendon and Section of the Anterior Joint Capsule Produce Moderate Osteoarthritic Changes in an Experimental Sheep Model.International journal of environmental research and public health · 2021Article
- Dimethyl Sulfoxide is Less Effective in Immersing Cryopreserved Large Pieces of Tissue: A Rabbit Hind-Limb Model.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
- Effects of Rolling-Sliding Mechanical Stimulation on Cartilage PreservedCellular and molecular bioengineering · 2019Article
- Advances in meniscal tissue engineering.Stem cells international · 2012Review
- Tissue engineering for rotator cuff repair: an evidence-based systematic review.Stem cells international · 2012Review
- Biological strategies to enhance healing of the avascular area of the meniscus.Stem cells international · 2012Article
- Stem cells and gene therapy for cartilage repair.Stem cells international · 2012Article
- Tissue engineered strategies for skeletal muscle injury.Stem cells international · 2012Review
- Scaffolds in tendon tissue engineering.Stem cells international · 2012Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo compare the integration of osteochondral allografts cryopreserved at different temperatures and different concentrations of dimethyl sulfoxide in an in vivo sheep animal model.
methodsThirty-six adult sheep were randomly allocated to 6 groups of allograft osteochondral transplantation. Six osteochondral cylinders were stored for 6 weeks at -80°C; 6 at -80°C with 10% dimethyl sulfoxide (DMSO); 6 at -80°C with 10% DMSO for 90 min; 6 at -186°C; 6 at -186°C with 10% DMSO; 6 at -186°C for 90 min. After transplantation, all animals were euthanized at 6 months. Harvested specimens underwent gross morphologic and histologic evaluation.
resultsWe found no statistically significant differences when comparing the gross cartilage morphology and histopathologic scores of each group. The Mankin and OARSI scores and the modified Wakitani and OARSI scores showed a good correlation grade. The Mankin and modified Wakitani scores showed a fair correlation grade.
conclusionThe cryopreservation protocols adopted in the present study provided scanty integration in an in vivo sheep model of osteochondral allograft transplantation. Therefore, their use in the clinical practice is discouraged.
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