ArticleIrish journal of medical science2011
Three generations of matrilineal excess of birth defects in Irish families with neural tube defects.
Article in Irish journal of medical science, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed, 3 citations in OpenAlex.
- Folate-related gene variants in Irish families affected by neural tube defects.Frontiers in genetics · 2013Article
- Periconceptional folic acid prevents miscarriage in Irish families with neural tube defects.Irish journal of medical science · 2011Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
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Abstract
backgroundNeural tube defects (NTDs) and birth defects overall are more likely to occur among maternal compared to paternal relatives in two generations (uncles/aunts and first cousins) of Irish families where an individual has been born with an NTD.
aimsThe aim of this study was to determine if the matrilineal excess persisted into the third generation.
methodsFirst cousins were interviewed about their pregnancy outcomes and their offsprings' health.
resultsMaternal first cousins once removed (FCOR) were more likely to have birth defects than paternal FCOR: 6.7 versus 3.5% (adjusted odds ratio 1.49, 95% CI 0.57, 3.89). No NTDs occurred. Folic acid supplementation significantly reduced the risk of birth defects (P = 0.04).
conclusionsThis study demonstrates an excess of birth defects among maternal relatives in three consecutive generations of NTD families, and supports the hypothesis that an underlying mechanism links distant maternal relatives in at least some NTD families.
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